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Gorpas, D. ; Ntziachristos, V.

Multi-parametric standards for performance assessment and quality control of fluorescence molecular imaging and endoscopy systems.

In: (Design and Quality for Biomedical Technologies XVIII, San Francisco). 1000 20th St, Po Box 10, Bellingham, Wa 98227-0010 Usa: SPIE, 2025. DOI: 10.1117/12.3041715 (Proc. SPIE ; 13308)
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Fluorescence molecular imaging (FMI) and endoscopy (FME) are technologies with great potential for image-guided surgical or diagnostic interventions. However, FMI and FME still present challenges that can confound real-time decision making for disease management and/or treatment. Importantly, the markedly different systems hurdle the repeatability of measurements, the unbiased readout interpretation, and the wide clinical acceptability of FMI and FME. Herein we present different multi-parametric standards to perform quality control and performance assessment of FMI and FME systems. Moreover, we discuss examples illustrating how data analysis and the design of fluorescence standards influence performance assessment outcomes, potentially affecting comparisons between systems or studies. We, also, show the first standard tailored to the requirements of FME and demonstrate its use for quality control of a fiberscope-based FME system. The discussed performance assessment and quality control framework can accelerate the clinical translation of fluorescence molecular imaging and endoscopy and steer further developments in the field.
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Publication type Article: Conference contribution
Keywords Fluorescence standards; performance assessment; quality control; fluorescence imaging
Language english
Publication Year 2025
HGF-reported in Year 2025
ISSN (print) / ISBN 0277-786X
e-ISSN 1996-756X
Conference Title Design and Quality for Biomedical Technologies XVIII
Conference Location San Francisco
Journal Proceedings of SPIE
Quellenangaben Volume: 13308 Issue: , Pages: , Article Number: , Supplement: ,
Publisher SPIE
Publishing Place 1000 20th St, Po Box 10, Bellingham, Wa 98227-0010 Usa
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-505500-001
Grants Horizon Europe - Pillar III
European Union's Horizon Europe research and innovation program
Copyright Copyright 2025 Society of Photo Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this publication for a fee or for commercial purposes, and modification of the contents of the publication are prohibited.
DOI 10.1117/12.3041715
WOS ID 001481034000001
Scopus ID 105004168695
Erfassungsdatum 2025-05-15
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