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Open Access Green as soon as Postprint is submitted to ZB.
Multi-parametric standards for performance assessment and quality control of fluorescence molecular imaging and endoscopy systems.
In: (Design and Quality for Biomedical Technologies XVIII, San Francisco). SPIE, 2025. DOI: 10.1117/12.3041715 (Proc. SPIE ; 13308)
Fluorescence molecular imaging (FMI) and endoscopy (FME) are technologies with great potential for image-guided
surgical or diagnostic interventions. However, FMI and FME still present challenges that can confound real-time decision
making for disease management and/or treatment. Importantly, the markedly different systems hurdle the repeatability of
measurements, the unbiased readout interpretation, and the wide clinical acceptability of FMI and FME. Herein we present
different multi-parametric standards to perform quality control and performance assessment of FMI and FME systems.
Moreover, we discuss examples illustrating how data analysis and the design of fluorescence standards influence
performance assessment outcomes, potentially affecting comparisons between systems or studies. We, also, show the first
standard tailored to the requirements of FME and demonstrate its use for quality control of a fiberscope-based FME system. The discussed performance assessment and quality control framework can accelerate the clinical translation of fluorescence molecular imaging and endoscopy and steer further developments in the field.
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Publication type
Article: Conference contribution
Keywords
Fluorescence standards; performance assessment; quality control; fluorescence imaging
ISSN (print) / ISBN
0277-786X
e-ISSN
1996-756X
Conference Title
Design and Quality for Biomedical Technologies XVIII
Conference Location
San Francisco
Journal
Proceedings of SPIE
Quellenangaben
Volume: 13308
Publisher
SPIE
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Biological and Medical Imaging (IBMI)
Copyright
Copyright 2025 Society of Photo Optical Instrumentation Engineers (SPIE). One print or electronic copy may be made for personal use only. Systematic reproduction and distribution, duplication of any material in this publication for a fee or for commercial purposes, and modification of the contents of the publication are prohibited."