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The role of moonlighting proteins in neurogenesis.
Curr. Opin. Neurobiol. 93:103047 (2025)
The complexity of the mammalian brain must arise from a comparably small number of genes. Proteins with moonlighting functions, i.e. entirely different functions in different compartments or cell types, contribute to multiply functional diversity. Here we review examples of such proteins with moonlighting functions during neurogenesis and in neuronal maturation. These range from cytoskeletal proteins acting as transcriptional regulators or synaptic proteins or exon junction proteins binding to and regulating the cytoskeleton to immediate early gene transcription factors regulating lipid metabolism in the endoplasmic reticulum. We further discuss how proteins with such moonlighting functions contribute to the heterogeneity of organelles shaping cell-type diversity in the brain.
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Publication type
Article: Journal article
Document type
Review
ISSN (print) / ISBN
0959-4388
e-ISSN
1873-6882
Journal
Current Opinion in Neurobiology
Quellenangaben
Volume: 93,
Article Number: 103047
Publisher
Elsevier
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Stem Cell Research (ISF)