PuSH - Publication Server of Helmholtz Zentrum München: Selective detection of superoxide by benzoselenadiazole based BODIPY probe: Synthesis and biological activity.

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Deshmukh, P.P.* ; Shelar, D. ; Dhavan, P.P. ; Jadhav, B.L.* ; Manjare, S.T.*

Selective detection of superoxide by benzoselenadiazole based BODIPY probe: Synthesis and biological activity.

Main Group Chem. 23, 473-482 (2025)

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Open Access Green as soon as Postprint is submitted to ZB.

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New benzoselenadiazole based BODIPY probe was synthesized and characterized with spectroscopic techniques like 1H, 13C, 77Se and mass spectrometry. The fluorescence of the probe quenched in the presence of superoxide ion, showing “Turn-off” response without interfering with other ROS even at higher concentrations. The detection limit was found to be 21.28μM. Kinetic study reveal the fast reaction between the probe and superoxide with good photostability. Also, the probe was studied for biological activity and found to be good agent for anti-inflammatory and antioxidant activities.

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