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De Backer, J.F.* ; Karges, T.* ; Papst, J.* ; Pınar, Z.N.* ; Coman, C.* ; Ahrends, R.* ; Xu, Y. ; García-Cáceres, C. ; Grunwald Kadow, I.C.*

Adenosine signaling in glia modulates metabolic state-dependent behavior in Drosophila.

Cell Rep. 44:115765 (2025)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
An animal's metabolic state strongly influences its behavior. Hungry animals prioritize food-seeking and feeding behaviors, while sated animals suppress these behaviors to engage in other activities. Additionally, neuronal activity and synaptic transmission are among the most energy-expensive processes. However, neurons do not uptake nutrients from the circulation. Instead, glia fulfill this highly evolutionarily conserved function in addition to modulating neuronal activity and behavior. However, how different glia subtypes sense metabolic state and modulate behavior is incompletely understood. Here, we unravel two types of glia-mediated modulation of metabolic-state-dependent behavior. In food-deprived flies, astrocyte-like and perineurial glia promote foraging and feeding, respectively, while cortex glia suppress these behaviors. We further show that adenosine and adenosine receptors modulate intracellular calcium levels in these glia subtypes, which ultimately controls behavior. This study reveals a mechanism of how different glia subtypes sense an animal's metabolic state and modulate its behavior accordingly.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Cp: Metabolism ; Drosophila ; Adenosine ; Chemosensation ; Feeding ; Glia ; Metabolic-state-dependent Behavior ; Metabolism ; Neural Circuits; Blood-brain-barrier; In-vivo; Astrocytes; Deaminase; Receptor; Neurons; System; Cells; Circuit; Valence
ISSN (print) / ISBN 2211-1247
e-ISSN 2211-1247
Journal Cell Reports
Quellenangaben Volume: 44, Issue: 6, Pages: , Article Number: 115765 Supplement: ,
Publisher Cell Press
Publishing Place 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Obesity (IDO)
Grants
Munich Cluster for Systems Neurology
Helmholtz Excellence Network
German Research Foundation (DFG)
State of North Rhine-Westphalia
German Research Foundation