PuSH - Publication Server of Helmholtz Zentrum München: The metabolic code of ferroptosis: Nutritional regulators of cell death.

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Tschuck, J. ; Skafar, V.* ; Friedmann Angeli, J.P.* ; Hadian, K.

The metabolic code of ferroptosis: Nutritional regulators of cell death.

Trends Biochem. Sci. 50, 663-676 (2025)

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Ferroptosis is a distinctive form of regulated cell death driven by iron-dependent phospholipid peroxidation. Its initiation and suppression are finely tuned by metabolic pathways, transcription factors, and nuclear receptors that control lipid peroxidation levels. Significantly, nutrients such as vitamins and trace elements play a pivotal role in this regulation, directly linking diet and nutrients to cellular fate. This review conveys the latest insights into the metabolic components that influence ferroptosis. We highlight how metabolic and transcriptional regulators and key nutrients, micronutrients, and metabolites orchestrate this process. Charting these interactions will be essential for developing new avenues for therapeutic interventions targeting ferroptosis in various diseases.

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