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Open Access Green as soon as Postprint is submitted to ZB.
Genetic background and 227Thorium as risk factors in biologically based models for induction of bone cancer in mice.
Radiat. Environ. Biophys. 51, 179-185 (2012)
We explore the potential for the biologically based two-stage clonal expansion model to make statements about the influence of genetic factors on the steps in the model. We find evidence that the different susceptibility of BALB/C and CBA/Ca mice to bone cancer after (227)Thorium injection may be mostly due to different promotional responses to radiation. In BALB/C × CBA/Ca back-crossed mice, we analyzed the specific contribution of two individual loci in the carcinogenic process. This analysis suggests that the two high- or low-risk alleles are acting on promotion or on the background parameters, but not on radiation-induced initiation. Taken together with the comparison of CBA/Ca and BALB/C mice, this hints at the possibility that the two loci are candidates for modifying radiation-induced promotion.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Genetic predisposition; (227)Thorium; Bone cancer; Biologically based model; ALPHA-EMITTERS; LUNG-CANCER; SMOKING; RATS; RADON; RADIATION; RA-224; TH-227; AGE
ISSN (print) / ISBN
0301-634X
e-ISSN
1432-2099
Quellenangaben
Volume: 51,
Issue: 2,
Pages: 179-185
Publisher
Springer
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Radiation Biology (ISB)