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Heidenreich, W.F. ; Rosemann, M.

Genetic background and 227Thorium as risk factors in biologically based models for induction of bone cancer in mice.

Radiat. Environ. Biophys. 51, 179-185 (2012)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
We explore the potential for the biologically based two-stage clonal expansion model to make statements about the influence of genetic factors on the steps in the model. We find evidence that the different susceptibility of BALB/C and CBA/Ca mice to bone cancer after (227)Thorium injection may be mostly due to different promotional responses to radiation. In BALB/C × CBA/Ca back-crossed mice, we analyzed the specific contribution of two individual loci in the carcinogenic process. This analysis suggests that the two high- or low-risk alleles are acting on promotion or on the background parameters, but not on radiation-induced initiation. Taken together with the comparison of CBA/Ca and BALB/C mice, this hints at the possibility that the two loci are candidates for modifying radiation-induced promotion.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Genetic predisposition; (227)Thorium; Bone cancer; Biologically based model; ALPHA-EMITTERS; LUNG-CANCER; SMOKING; RATS; RADON; RADIATION; RA-224; TH-227; AGE
ISSN (print) / ISBN 0301-634X
e-ISSN 1432-2099
Journal Radiation and Environmental Biophysics
Quellenangaben Volume: 51, Issue: 2, Pages: 179-185 Article Number: , Supplement: ,
Publisher Springer
Reviewing status Peer reviewed
Institute(s) Institute of Radiation Biology (ISB)