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Lattka, E. ; Klopp, N. ; Demmelmair, H.* ; Klingler, M.* ; Heinrich, J. ; Koletzko, B.*

Genetic variations in polyunsaturated fatty acid metabolism - implications for child health?

Ann. Nutr. Metab. 60, 3, 8-17 (2012)
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Sufficient nutritional supply with polyunsaturated fatty acids (PUFAs) has long been considered as beneficial for child health, especially in regard to neuronal development and allergic diseases. In recent years, genetic association studies showed that in addition to nutritional influences, the genetic background is highly important for PUFA composition in human tissues. Specifically, polymorphisms in the fatty acid desaturase genes or FADS determine the efficiency of how PUFAs are processed endogenously. Recent gene-nutrition interaction studies suggest that these polymorphisms modulate the effect of nutritional fatty acid intake on complex phenotypes such as cognitive outcomes and asthma risk in children. These early results may provide the basis for future well-specified dietary recommendations to achieve optimal health benefit for all children. This article presents results from recent gene-nutrition interaction studies, discusses its implications for child health, and gives an outlook how this association might translate into clinical practice in the future.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Allergy; Breastfeeding; Cognition; Δ5-Desaturase; Δ6-Desaturase; FADS1; FADS2; Gene-nutrition interaction; Long-chain polyunsaturated fatty acids; Single nucleotide polymorphisms
Language english
Publication Year 2012
HGF-reported in Year 2012
ISSN (print) / ISBN 0250-6807
e-ISSN 1421-9697
Journal Annals of Nutrition and Metabolism
Quellenangaben Volume: 60, Issue: , Pages: 8-17, Article Number: , Supplement: 3
Publisher Karger
Reviewing status Peer reviewed
Institute(s) Research Unit Molecular Epidemiology (AME)
Institute of Epidemiology (EPI)
POF-Topic(s) 30501 - Systemic Analysis of Genetic and Environmental Factors that Impact Health
30503 - Chronic Diseases of the Lung and Allergies
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504200-001
G-503900-001
PubMed ID 22614814
DOI 10.1159/000337308
Scopus ID 84861424065
Erfassungsdatum 2012-06-06
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