PuSH - Publication Server of Helmholtz Zentrum München

Hampel, R. ; Breitner-Busch, S. ; Zareba, W.* ; Kraus, U. ; Pitz, M. ; Geruschkat, U. ; Belcredi, P. ; Peters, A. ; Schneider, A.E. ; KORA Study Group (Wichmann, H.-E. ; Holle, R. ; John, J. ; Illig, T. ; Meisinger, C. ; Peters, A.)

Immediate ozone effects on heart rate and repolarisation parameters in potentially susceptible individuals.

Occup. Environ. Med. 69, 428-436 (2012)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Objectives Elevated ozone levels have been associated with cardiovascular morbidity and mortality. We investigated the effects of ozone on heart rate (HR) and repolarisation parameters in potentially susceptible populations. Methods Between March 2007 and December 2008, 363 ECG recordings including >2000 1 h intervals were measured in 64 individuals with type 2 diabetes or impaired glucose tolerance and in 46 healthy individuals with a potential genetic predisposition on the detoxification pathways from Augsburg, Germany. Associations between 1 h averages of ozone and HR, Bazett-corrected QT-interval (QTc), T-wave amplitude and T-wave complexity were analysed using additive mixed models. A variable indicating season and participants' location during the 1 h ECG recordings (summer and outdoors vs winter or indoors) was used as a potential ozone effect modifier. Results We observed concurrent and 1-4 h lagged increases in HR of 0.5-0.7% for each 20 μg/m(3) increase in ozone. These effects were stronger (1.0-1.2%) when participants were outdoors during the summer. We detected in all participants a concurrent (-1.31%; 95% CI -2.19% to -0.42%) and 1 h lagged (-1.32%; -2.19% to -0.45%) T-wave flattening. Elevated ozone levels were associated with 1 h (2.12%; 0.81 to 3.52) and 2 h lagged (1.89%; 0.55% to 3.26%) increases in T-wave complexity. However, no effects were seen for QTc. Ozone effects were generally more pronounced in individuals with metabolic disorders than a potential genetic predisposition. Conclusions Changes in repolarisation might contribute to underlying pathophysiological changes associated with the link between elevated ozone levels and reported adverse cardiovascular outcomes.
Altmetric
Additional Metrics?
[➜Log in]
Edit extra informations Login
Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords PARTICULATE AIR-POLLUTION; CASE-CROSSOVER ANALYSIS; T-WAVE ABNORMALITIES; RATE-VARIABILITY; MYOCARDIAL-INFARCTION; OXIDATIVE STRESS; SENIOR ADULTS; URBAN AIR; MORTALITY; ASSOCIATION
ISSN (print) / ISBN 1351-0711
e-ISSN 1470-7926
Journal Occupational and Environmental Medicine
Quellenangaben Volume: 69, Issue: 6, Pages: 428-436 Article Number: , Supplement: ,
Publisher BMJ Publishing Group
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology II (EPI2)