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Liu, Y.-H. ; Schneider, R.

Histone modifications in development.

Development 152:dev204384 (2025)
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In eukaryotic cells, the genetic material is organized into chromatin, which consists mainly of DNA, histones and chromatin-associated proteins. An important regulator of chromatin structure and function are histone post-translational modifications, which can shape gene expression patterns and control the epigenetic landscape. Here, we summarize the role of some key histone modifications in animal development, with a focus on the two best-studied types of histone modifications: lysine methylation and acylations, specifically, acetylation.
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Publication type Article: Journal article
Document type Review
Keywords Acetylation ; Histone Modification ; Methylation ; Mutation; Molecular-mechanisms; Chromatin-structure; Gene-expression; Lateral Surface; Acetylation; H3; Phosphorylation; Transcription; Nucleosome; Differentiation
Language english
Publication Year 2025
HGF-reported in Year 2025
ISSN (print) / ISBN 0950-1991
e-ISSN 1477-9129
Journal Development / Company of Biologists
Quellenangaben Volume: 152, Issue: 12, Pages: , Article Number: dev204384 Supplement: ,
Publisher Company of Biologists
Publishing Place Bidder Building, Station Rd, Histon, Cambridge Cb24 9lf, England
Reviewing status Peer reviewed
Institute(s) Institute of Functional Epigenetics (IFE)
POF-Topic(s) 30203 - Molecular Targets and Therapies
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502800-001
Grants Helmholtz-Gemeinschaft
DOI 10.1242/dev.204384
WOS ID 001525256900001
Scopus ID 105008836393
PubMed ID 40514762
Erfassungsdatum 2025-07-08
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