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Dipol, T.* ; Fortuna, A.* ; Morsilli, O.* ; Zecca, V.* ; Singh, T.* ; Palombelli, G.* ; Mattei, F.* ; Favero, V.* ; Candelise, N.* ; Maroccia, Z.* ; Loizzo, A.* ; Rimondini, R.* ; Campana, G.* ; Pellegata, N.S. ; Loizzo, S.* ; Canese, R.* ; Chiodini, I.*

Mild chronic post-natal pain induces endocrine and metabolic alterations associated to enlargement in pituitary glands size in adult CD-1 male mice.

Endocrine, DOI: 10.1007/s12020-025-04297-6 (2025)
Postprint DOI PMC
Open Access Green
BACKGROUND: Human adverse childhood experiences (ACEs) are associated with various types of mental and physical pathological outcomes in adulthood. Among them, they may present the enlargement of the pituitary gland and have been suggested to be a risk factor for the development of Cushing syndrome. Previously, we showed on outbred CD-1 male mice that chronic pain induced during the weaning time by pharmacological experimental design procedures caused endocrine and metabolic alterations in adulthood, suggestive of human mild hypercortisolism. Specifically, we observed an increase in pituitary glands weight and in adrenocorticotropic hormone (ACTH) expression, associated with the lack of the negative feedback mechanisms exerted by corticosterone that controls proopiomelanocortin- derived ACTH secretion. METHODS: Here, to better understand the phenotype of mice subjected to early-life pain (ELP), their pituitary glands were examined. Mice tissues and plasma hormones measurements were conducted by ELISA assays. Analysis of brain and pituitary gland was performed using anatomic and diffusion-weighted magnetic resonance imaging. Hematoxylin and eosin-stained sections of pituitary glands were also examined. RESULTS: Mice subjected to ELP showed an increase in total body weight, in pituitary ACTH expression and in plasmatic corticosterone levels. Imaging of the pituitary glands revealed a significant increment of their volume without apparent pathological alterations. CONCLUSION: The findings of this study may support the role of ELP as a risk factor for ACTH-dependent hypercortisolism in adulthood associated with an enlarged pituitary gland.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Cushing Syndrome ; Early-life Pain ; Magnetic Resonance Imaging ; Pituitary Gland; Early-life Stress; Cortisol; Adolescence
Language english
Publication Year 2025
HGF-reported in Year 2025
ISSN (print) / ISBN 1355-008X
e-ISSN 1559-0100
Journal Endocrine
Publisher Springer
Publishing Place Totowa, NJ
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes and Cancer (IDC)
POF-Topic(s) 30201 - Metabolic Health
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-502590-001
DOI 10.1007/s12020-025-04297-6
WOS ID 001507809900001
Scopus ID 105007917707
PubMed ID 40514619
Erfassungsdatum 2025-07-08
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