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Shan, X.* ; Sawangjit, A.* ; Born, J. ; Inostroza, M.*

Rearing behavior as indicator of spatial novelty and memory in developing rats.

Eur. J. Neurosci. 61:e70162 (2025)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold (Paid Option)
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Among the various forms of exploration, rearing-where rodents stand on their hind legs-reflects the animal's processing of spatial information and response to environmental novelty. Here, we investigated the developmental trajectory of rearing in response to spatial novelty in a standard object-place recognition (OPR) task, with the OPR retrieval phase allowing for a direct comparison of measures of rearing, object exploration, and locomotion as indicators of spatial novelty and memory. Groups of male rats were tested on postnatal day (PD) 25, PD31, PD38, PD48, and at adulthood (PD84). The OPR task comprised a 5-min encoding phase with the rat exposed to an arena with two identical objects and, 3 h later, a 5-min retrieval phase in the same arena with one object being displaced to another arena zone. Rearing increased in response to spatial novelty (i.e., the displaced object) at retrieval relative to encoding, with this increase occurring first on PD31, and thus later than preferential object exploration-based responses emerging already on PD25. Importantly, zone-specific analyses during retrieval revealed an increase in rearing events in the (now empty) zone where the displaced object is used to be at encoding. This increase was only observed in adult rats (PD84) and likely indicates the presence of specific object-place associations in memory. These findings evidence rearing as behavior covering aspects of spatial novelty complementary to those of object exploration, thereby enabling a more comprehensive characterization of the emergence of spatial episodic memory during early life.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Developmental Trajectory ; Exploratory Behavior ; Object–place Recognition ; Spatial Episodic Memory ; Spatial Learning; Lateral Entorhinal Cortex; Prefrontal Cortex; Object-location; Recognition; Place; Hippocampus; Maturation; Context; Mechanisms; Damage
ISSN (print) / ISBN 0953-816X
e-ISSN 1460-9568
Journal European Journal of Neuroscience
Quellenangaben Volume: 61, Issue: 12, Pages: , Article Number: e70162 Supplement: ,
Publisher Wiley
Publishing Place 111 River St, Hoboken 07030-5774, Nj Usa
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Diabetes Research and Metabolic Diseases (IDM)
Grants The H2020 European Research Council
China Scholarship Council
Deutsche Forschungsgemeinschaft