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Oxidative phosphorylation in uncoupled mitochondria.
Bioessays:e70038 (2025)
Mitochondrial membrane potential is highly dependent on coupled as well as uncoupled respiration. While brown adipose tissue (BAT) mediates non-shivering thermogenesis (NST), a highly adaptive bioenergetic process critical for energy metabolism, the relationship of coupled and uncoupled respiration in thermogenic adipocytes remains complicated. Uncoupling protein 1 (UCP1)-mediated proton leak is the primary driver of NST, but recent studies have shown that oxidative phosphorylation may be an underappreciated contributor to UCP1-dependent NST. Here, we highlight the role of ATP synthase for BAT thermogenesis and discuss the implications of fine-tuning adrenergic signaling in brown adipocytes by the protein inhibitory factor 1 (IF1). We conclude by hypothesizing future directions for mitochondrial research, such as investigating the potential role of IF1 for mitochondrial substrate preference, structural dynamics, as well as its role in cell fate decision and differentiation.
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Publication type
Article: Journal article
Document type
Review
Keywords
Ucp1 ; Adipocytes ; Bioenergetics ; Metabolism ; Mitochondria ; Obesity ; Thermogenesis; Brown Adipose-tissue; Atpase Inhibitory Factor-1; Regulatory Protein; Synthase; F0f1-atpase; Metabolism; Expression; Mechanism
ISSN (print) / ISBN
0265-9247
e-ISSN
1521-1878
Journal
BioEssays
Quellenangaben
Article Number: e70038
Publisher
Wiley
Publishing Place
111 River St, Hoboken 07030-5774, Nj Usa
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Cancer (IDC)
Grants
Deutsche Forschungsgemeinschaft