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FMT-XCT: In vivo animal studies with hybrid fluorescence molecular tomography-X-ray computed tomography.
Nat. Methods 9, 615-620 (2012)
The development of hybrid optical tomography methods to improve imaging performance has been suggested over a decade ago and has been experimentally demonstrated in animals and humans. Here we examined in vivo performance of a camera-based hybrid fluorescence molecular tomography (FMT) system for 360° imaging combined with X-ray computed tomography (XCT). Offering an accurately co-registered, information-rich hybrid data set, FMT-XCT has new imaging possibilities compared to stand-alone FMT and XCT. We applied FMT-XCT to a subcutaneous 4T1 tumor mouse model, an Aga2 osteogenesis imperfecta model and a Kras lung cancer mouse model, using XCT information during FMT inversion. We validated in vivo imaging results against post-mortem planar fluorescence images of cryoslices and histology data. Besides offering concurrent anatomical and functional information, FMT-XCT resulted in the most accurate FMT performance to date. These findings indicate that addition of FMT optics into the XCT gantry may be a potent upgrade for small-animal XCT systems.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
DIFFUSE OPTICAL TOMOGRAPHY; LUNG-CANCER; REGULARIZATION; BREAST; PET/CT; MODEL; MRI
ISSN (print) / ISBN
1548-7091
e-ISSN
1548-7105
Journal
Nature Methods
Quellenangaben
Volume: 9,
Issue: 6,
Pages: 615-620
Publisher
Nature Publishing Group
Publishing Place
New York, NY
Non-patent literature
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Reviewing status
Peer reviewed