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Subochev, P.V.* ; Deán-Ben, X.L.* ; Chen, Z.* ; Prudnikov, M.B.* ; Vorobev, V.A.* ; Kurnikov, A.A.* ; Orlova, A.G.* ; Postnikova, A.S.* ; Kharitonov, A.V.* ; Proyavin, M.D.* ; Ovsyannikov, R.I.* ; Sanin, A.G.* ; Kirillin, M.Y.* ; Montero de Espinosa, F.* ; Turchin, I.V.* ; Razansky, D.

Ultrawideband high density polymer-based spherical array for real-time functional optoacoustic micro-angiography.

Light Sci. Appl. 14:239 (2025)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Owing to its unique ability to capture volumetric tomographic information with a single light flash, optoacoustic (OA) tomography has recently demonstrated ultrafast imaging speeds ultimately limited by the ultrasound time-of-flight. The method's scalability and the achievable spatial resolution are yet limited by the narrow bandwidth of piezo-composite arrays currently employed for OA signal detection. Here we report on the first implementation of high-density spherical array technology based on flexible polyvinylidene difluoride films featuring ultrawideband (0.3-40 MHz) sub mm2 area elements, thus enabling real-time multi-scale volumetric imaging with 22-35 µm spatial resolution, superior image fidelity and over an order of magnitude signal-to-noise enhancement compared to piezo-composite equivalents. We further demonstrate five-dimensional (spectroscopic, time-resolved, volumetric) imaging capabilities by visualizing fast stimulus-evoked cerebral oxygenation changes in mice and performing real-time functional angiography of deep human micro-vasculature. The new technology thus leverages the true potential of OA for quantitative high-resolution visualization of rapid bio-dynamics across scales.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Photoacoustic Tomography; Optical-properties; Parameters
ISSN (print) / ISBN 2047-7538
e-ISSN 2047-7538
Journal Light: Science & Applications
Quellenangaben Volume: 14, Issue: 1, Pages: , Article Number: 239 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
Grants Helmholtz Association
Russian Science Foundation
European Research Council
Swiss National Science Foundation