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Katahira, I.* ; Liebrand, N.* ; Gorzkiewicz, M.* ; Klahm, N.P.* ; Abromavičiūtė, D.* ; Werner, J.* ; Krings, K.S.* ; Orywol, S.* ; Lautwein, T.* ; Köhrer, K.* ; Herebian, D.* ; Mayatepek, E.* ; Anstötz, M.* ; Bergmann, A.K.* ; Kondadi, A.K.* ; Xu, H.C.* ; Pandyra, A.A.* ; Kobayashi, T.* ; Brenner, D.* ; Floss, T. ; Kalinke, U.* ; Reichert, A.S.* ; Lang, P.A.*

Controlling mitochondrial membrane architecture via MIC60 determines viral replication to promote anti-viral immunity.

Cell Rep. 44:115922 (2025)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Virus-infected cells often exhibit dramatic cellular changes accompanied by altered mitochondrial function. The contribution of factors shaping the inner mitochondrial membrane (IMM) and cristae architecture to viral replication is insufficiently understood. Single-cell transcriptomics applying vesicular stomatitis virus infection suggests involvement of factors determining IMM architecture following infection. Consistently, inhibition of the F1FO adenosine triphosphate (ATP) synthase reduces viral replication, which is associated with oligomerization of this complex and altered IMM structure. Moreover, deletion of mitochondrial contact site and cristae organizing system (MICOS) complex by targeting MIC60 results in reduced viral replication. Generation of Mic60inv/invCD11c-Cre+ mice uncovers reduced crista junctions and viral replication in bone marrow-derived dendritic cells. Consequently, reduced viral replication in CD11c-expressing cells limits prolonged immune activation. Altogether, by linking the F1FO ATP synthase and the MICOS complex to viral replication and immune activation, we describe links between the mitochondrial structure-metabolism and the immune response against viral infection.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Bmdc ; Cp: Cell Biology ; Cp: Microbiology ; Mic60 ; Micos ; Immunometabolism ; Innate Immunity ; Inner Mitochondrial Membrane ; Itaconate ; Mitochondria ; Viral Infection; Dendritic Cells; Functional-analysis; Atp Synthase; Contact Site; Cristae; Infection; Complex; Protein; Micos; Organization
Language english
Publication Year 2025
HGF-reported in Year 2025
ISSN (print) / ISBN 2211-1247
e-ISSN 2211-1247
Journal Cell Reports
Quellenangaben Volume: 44, Issue: 7, Pages: , Article Number: 115922 Supplement: ,
Publisher Cell Press
Publishing Place 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Reviewing status Peer reviewed
Institute(s) Institute of Developmental Genetics (IDG)
POF-Topic(s) 30204 - Cell Programming and Repair
Research field(s) Genetics and Epidemiology
PSP Element(s) G-500500-001
Grants Medical Faculty of the Heinrich Heine University (Forschungskommission)
German Ministry for Education and Research (Bundesministerium fur Bildung und Forschung BMBF)
DOI 10.1016/j.celrep.2025.115922
WOS ID 001540514100002
Scopus ID 105009882864
PubMed ID 40628273
Erfassungsdatum 2025-07-18
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