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Feng, J.W.* ; Pidon, H.* ; Cuacos, M.* ; Lux, T. ; Himmelbach, A.* ; Haghi, R.* ; Fuchs, J.* ; Haberer, G. ; Kuo, Y.T.* ; Guo, Y.* ; Jayakodi, M.* ; Toegelová, H.* ; Harpke, D.* ; Knauft, M.* ; Fiebig, A.* ; Maruschewski, M.* ; Ronen, M.* ; Sharon, A.* ; Šimková, H.* ; Mayer, K.F.X. ; Spannagl, M. ; Kumlehn, J.* ; Heckmann, S.* ; Houben, A.* ; Blattner, F.R.* ; Stein, N.* ; Mascher, M.*

A haplotype-resolved pangenome of the barley wild relative Hordeum bulbosum.

Nature, DOI: 10.1038/s41586-025-09270-x (2025)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold (Paid Option)
Creative Commons Lizenzvertrag
Wild plants can contribute valuable genes to their domesticated relatives1. Fertility barriers and a lack of genomic resources have hindered the effective use of crop-wild introgressions. Decades of research into barley's closest wild relative, Hordeum bulbosum, a grass native to the Mediterranean basin and Western Asia, have yet to manifest themselves in the release of a cultivar bearing alien genes2. Here we construct a pangenome of bulbous barley comprising 10 phased genome sequence assemblies amounting to 32 distinct haplotypes. Autotetraploid cytotypes, among which the donors of resistance-conferring introgressions are found, arose at least twice, and are connected among each other and to diploid forms through gene flow. The differential amplification of transposable elements after barley and H. bulbosum diverged from each other is responsible for genome size differences between them. We illustrate the translational value of our resource by mapping non-host resistance to a viral pathogen to a structurally diverse multigene cluster that has been implicated in diverse immune responses in wheat and barley.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords Gene; Rna; Resistance; Phylogeny; Sequence; History; Identification; Methodology; Annotation; Inference
ISSN (print) / ISBN 0028-0836
e-ISSN 1476-4687
Journal Nature
Publisher Nature Publishing Group
Publishing Place London
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Research Unit Plant Genome and Systems Biology (PGSB)
Grants
German federal state of Saxony-Anhalt
German Federal Ministry of Education and Research (BMBF)
European Commission (ERC)
IPK core funding