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Development of a circadian immune system.
Trends Immunol. 46, 614-623 (2025)
Circadian rhythms are key regulators of immune functions. These endogenous oscillations help to maintain immune homeostasis, regulate responses to pathogens, and shape vaccine efficacy. Recent studies further indicate that they are of clinical relevance for cancer immunotherapies. While circadian immune rhythms are thus recognized to be important in adults, it is unknown at what developmental stage these rhythms begin to manifest. In this opinion article we review the development of circadian rhythms in the immune system in both rodents and humans, with a focus on their interactions during the perinatal period. Understanding their emergence in early life may help guide time-based clinical interventions for infants.
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Publication type
Article: Journal article
Document type
Review
Keywords
Breast Milk ; Circadian Rhythms ; Immune System Development ; Maternal Behavior ; Neonatal; Suprachiasmatic Nucleus; Newborn; Clock; Expression; Responses; Ontogeny; Neurons; Rhythm; Fetal
ISSN (print) / ISBN
1471-4906
e-ISSN
1471-4981
Journal
Trends in Immunology
Quellenangaben
Volume: 46,
Issue: 9,
Pages: 614-623
Publisher
Elsevier
Publishing Place
50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Reviewing status
Peer reviewed
Institute(s)
Institute of Translational Genomics (ITG)
Grants
Translational Research Center in Oncohaematology (CRTOH)
Geneva Cancer League
Swiss Cancer Research
Swiss National Science Foundation (SNF)
European Research Council (CIRCADYN)
German Research Foundation (DFG)
Geneva Cancer League
Swiss Cancer Research
Swiss National Science Foundation (SNF)
European Research Council (CIRCADYN)
German Research Foundation (DFG)