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Li, X.* ; Rothämel, P. ; Nussbaum, C.* ; Sperandio, M.* ; Scheiermann, C.*

Development of a circadian immune system.

Trends Immunol. 46, 614-623 (2025)
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Circadian rhythms are key regulators of immune functions. These endogenous oscillations help to maintain immune homeostasis, regulate responses to pathogens, and shape vaccine efficacy. Recent studies further indicate that they are of clinical relevance for cancer immunotherapies. While circadian immune rhythms are thus recognized to be important in adults, it is unknown at what developmental stage these rhythms begin to manifest. In this opinion article we review the development of circadian rhythms in the immune system in both rodents and humans, with a focus on their interactions during the perinatal period. Understanding their emergence in early life may help guide time-based clinical interventions for infants.
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Publication type Article: Journal article
Document type Review
Keywords Breast Milk ; Circadian Rhythms ; Immune System Development ; Maternal Behavior ; Neonatal; Suprachiasmatic Nucleus; Newborn; Clock; Expression; Responses; Ontogeny; Neurons; Rhythm; Fetal
Language english
Publication Year 2025
HGF-reported in Year 2025
ISSN (print) / ISBN 1471-4906
e-ISSN 1471-4981
Journal Trends in Immunology
Quellenangaben Volume: 46, Issue: 9, Pages: 614-623 Article Number: , Supplement: ,
Publisher Elsevier
Publishing Place 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Reviewing status Peer reviewed
Institute(s) Institute of Translational Genomics (ITG)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-506700-001
Grants Translational Research Center in Oncohaematology (CRTOH)
Geneva Cancer League
Swiss Cancer Research
Swiss National Science Foundation (SNF)
European Research Council (CIRCADYN)
German Research Foundation (DFG)
DOI 10.1016/j.it.2025.06.004
WOS ID 001571800200001
Scopus ID 105010321869
PubMed ID 40653412
Erfassungsdatum 2025-07-22
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