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Diexer, S.* ; Frost, J.* ; Ahnert, P.* ; Baernighausen, T.W.* ; Brenner, H.* ; Fricke, J.* ; Gabrysch, S.* ; Greiser, K.H.* ; Harth, V.* ; Heise, J.K.* ; Kaaks, R.* ; Karch, A.* ; Keil, T.* ; Klee, B.* ; Klett-Tammen, C.J.* ; Krist, L.* ; Lampl, B.M.J.* ; Leitzmann, M.F.* ; Lieb, W.* ; Meinke-Franze, C.* ; Michels, K.B.* ; Velásquez, I.M.* ; Obi, N.* ; Peters, A. ; Pfrommer, L.R.* ; Pischon, T.* ; Purschke, O.* ; Rübsamen, N.* ; Schikowski, T.* ; Schmidt, B.* ; Thierry, S. ; Völzke, H.* ; Wright, M.N.* ; Zeeb, H.* ; Mikolajczyk, R.*

Cross-sectional study of health impairment related to post COVID-19 condition among participants of a large population-based cohort in Germany.

Sci. Rep. 15:25830 (2025)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Post COVID-19 condition (PCC) is a substantial burden for patients, society, and the healthcare system. Participants of the German National Cohort (NAKO) were asked in an online survey about their self-perceived health, symptoms related to PCC, and infection status. PCC was defined as reporting symptoms for the time window 4-12 months after infection. Of 110,375 respondents (73% response), 86,833 were included in this analysis. Of these, 44,451 (51%) did not report a SARS-CoV-2 infection (no infection), 26,726 (31%) reported an infection but no symptoms 4-12 months after infection (infection/no PCC), and 15,656 (18%) reported an infection and symptoms (PCC). The median number of current symptoms at the time of the survey was two for the "no infection" and the "infection/no PCC" group, and five for the "PCC" group. Participants with PCC had a substantially higher probability of having worse self-perceived health (OR 1.84, 95% CI [1.75; 1.93] compared to the "no infection" group, adjusting for sex, age, education and chronic diseases with elevated risk for developing PCC. After adjusting for the number of current symptoms related to PCC, this difference disappeared, suggesting that the symptoms collected explain the impairment of self-perceived health in the PCC group.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Perceived Health; Survey Sf-36; Symptoms; Validity; Impact
Language english
Publication Year 2025
HGF-reported in Year 2025
ISSN (print) / ISBN 2045-2322
e-ISSN 2045-2322
Journal Scientific Reports
Quellenangaben Volume: 15, Issue: 1, Pages: , Article Number: 25830 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Epidemiology (EPI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-504000-010
G-504000-007
Grants Federal Ministry of Education and Re-search (BMBF)
German National Cohort (NAKO)
Projekt DEAL
DOI 10.1038/s41598-025-07894-7
WOS ID 001530795100003
Scopus ID 105010860573
PubMed ID 40670423
Erfassungsdatum 2025-07-18
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