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Röllke, L.* ; Schacher, B.* ; Wohlfeil, M.* ; Kim, T.-S.* ; Kaltschmitt, J.* ; Krieger, J.* ; Krigar, D.M.* ; Reitmeir, P. ; Eickholz, P.*

Regenerative therapy of infrabony defects with or without systemic doxycycline. A randomized placebo-controlled trial.

J. Clin. Periodontol. 39, 448-456 (2012)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
AIM: Comparison of regenerative therapy of infrabony defects with and without administration of postsurgical systemic doxycycline (DOXY). METHODS: In each of 61 patients one infrabony defect was treated with enamel matrix derivative (EMD), EMD plus filler or membrane at two centres. By random assignment patients received either 200 mg DOXY per day or placebo (PLAC) for 7 days after surgery. Prior to and 6 months after surgery probing pocket depths (PPD) and vertical attachment level (PAL-V) were obtained. RESULTS: Fifty-four patients (DOXY: 27; PLAC: 27) were re-examined after 6 months and had been treated exclusively with EMD. Seven to 8 days after surgery 81% of defects in both groups showed complete flap closure. In both groups significant (p < 0.001) PPD reduction (DOXY: 3.87 ± 1.44 mm; PLAC: 3.67 ± 1.30 mm) and PAL-V gain (DOXY: 3.11 ± 1.50 mm; PLAC: 3.32 ± 1.83 mm) were observed. However, the differences failed to be statistically significant (PPD: 0.20; p = 0.588; PAL-V: 0.21; p = 0.657). CONCLUSIONS: Two hundred milligram systemic DOXY administered for 7 days after therapy of infrabony defects with EMD failed to result in better PPD reduction and PAL-V gain compared with PLAC which may be due to low power (50%) and, thus, random chance.
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Publication type Article: Journal article
Document type Scientific Article
Corresponding Author
Keywords doxycycline; early wound-healing; infrabony defects; periodontal disease; regenerative therapy: enamel matrix derivative; CONTROLLED CLINICAL-TRIAL; GUIDED TISSUE REGENERATION; ENAMEL MATRIX PROTEINS; DEEP INTRABONY DEFECTS; PAPILLA PRESERVATION FLAP; BIOABSORBABLE BARRIERS; PERIODONTAL SURGERY; BONY DEFECTS; POSTSURGICAL ANTIBIOTICS; FURCATION DEFECTS
ISSN (print) / ISBN 0303-6979
e-ISSN 1600-051X
Journal Journal of Clinical Periodontology
Quellenangaben Volume: 39, Issue: 5, Pages: 448-456 Article Number: , Supplement: ,
Publisher Wiley
Non-patent literature Publications
Reviewing status Peer reviewed
Institute(s) Institute of Health Economics and Health Care Management (IGM)