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Fasting-regulated mechanisms in inter-organ crosstalk.
Curr. Opin. Endocr. Metab. Res. 36:100540 (2024)
The adaptation to changing environmental cues represents a key prerequisite for the survival of an organism. Mammals, including humans, have evolved intricate endocrine signals to convey information about the nutritional status to individual organs, cells, and eventually the cell nucleus, to trigger appropriate molecular-metabolic responses. To this end, mounting a proper fasting response is determined by not only intra-organ adaptations but also inter-tissue crosstalk mechanisms that orchestrate whole-body energy homeostasis under nutrient-deprived conditions. Here, we shortly summarize recent advances in our current understanding of the key processes driving the adaptive response to fasting with a focus on the crosstalk between the adipose tissue and liver ketogenesis.
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Publication type
Article: Journal article
Document type
Review
ISSN (print) / ISBN
2451-9650
e-ISSN
2451-9650
Quellenangaben
Volume: 36,
Article Number: 100540
Publisher
Elsevier
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Cancer (IDC)