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Li, Q.* ; Ali, Z. ; Zakian, C. ; Di Pietro, M.* ; Honing, J.* ; O'Donovan, M.* ; Flisikowski, K.* ; Sarantos, V.* ; Pierre, G.* ; Gloriod, J.* ; Drexler, W.* ; Ntziachristos, V.

Tethered optoacoustic and optical coherence tomography capsule endoscopy for label-free assessment of Barrett's oesophageal neoplasia.

Nat. Bio. Eng., DOI: 10.1038/s41551-025-01462-0 (2025)
Publ. Version/Full Text Research data DOI PMC
Open Access Hybrid
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Endoscopic detection of oesophageal cancer (EC) often occurs late in disease development, leading to high mortality rates. Improved technologies are urgently needed for earlier EC detection. Here we research an endoscopic ultra-broadband acoustic detection scheme and introduce a 360-degree hybrid optoacoustic and optical coherence endoscopy to enable interrogation of surface and subsurface precancerous and cancerous features at a three-dimensional micrometre scale. In the following pilot tissue investigation, the dual-modal imaging features are assessed for classifying different mucosal types in Barrett's oesophagus (BE)-a precursor of EC. We find that human lesions of different grades, such as metaplastic, dysplastic and cancerous mucosa, exhibit distinctly different imaging features that are unique to the hybrid modality. Based on these features, a classification system is developed and evaluated for identifying BE neoplasia. The results show accurate BE neoplasia detection due to the complementarity of the two imaging modalities. Therefore, this study highlights the ability of the new dual-modality feature set to improve the detection performance of any of the two modalities operating in stand-alone mode and enhance diagnostic accuracy.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Volumetric Laser Endomicroscopy; Squamous-cell Carcinoma; Blue-directed Biopsies; Intestinal Metaplasia; In-vivo; Dysplasia; Diagnosis; Surveillance; Management; Adenocarcinoma
Language english
Publication Year 2025
HGF-reported in Year 2025
ISSN (print) / ISBN 2157-846X
e-ISSN 2157-846X
Journal Nature biomedical engineering
Publisher Nature Publishing Group
Publishing Place London ; New York NY ; Tokyo
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-505500-001
Grants European Union
EC | Horizon 2020 Framework Programme (EU Framework Programme for Research and Innovation H2020)
DOI 10.1038/s41551-025-01462-0
WOS ID 001545118200001
Scopus ID 105012844667
PubMed ID 40770504
Erfassungsdatum 2025-11-05
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