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Cortex folding by combined progenitor expansion and adhesion-controlled neuronal migration.
Nat. Commun. 16:8048 (2025)
Folding of the mammalian cerebral cortex into sulcal fissures and gyral peaks is the result of complex processes that are incompletely understood. Previously we showed that genetic deletion of Flrt1/3 adhesion molecules causes folding of the smooth mouse cortex into sulci resulting from increased lateral dispersion and faster neuron migration, without progenitor expansion. Here, we show in mice that combining the Flrt1/3 double knockout with an additional genetic deletion that causes progenitor expansion, greatly enhances cortex folding. Expansion of intermediate progenitors by deletion of Cep83 leads to a relative increase in Flrt-mutant neurons resulting in enhanced formation of sulci. Expansion of apical progenitors by deletion of Fgf10 leads to a relative reduction in Flrt-mutant neurons resulting in enhanced formation of gyri. These results together with computational modeling identify key developmental mechanisms, such as adhesive properties, cell densities and migration of cortical neurons, that cooperate to promote cortical gyrification.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Cerebral-cortex; Radial Glia; Cell-proliferation; Brain; Size; Differentiation; Ferret
ISSN (print) / ISBN
2041-1723
e-ISSN
2041-1723
Journal
Nature Communications
Quellenangaben
Volume: 16,
Issue: 1,
Article Number: 8048
Publisher
Nature Publishing Group
Publishing Place
London
Reviewing status
Peer reviewed
Institute(s)
Institute for Intelligent Biotechnologies (IBIO)
Grants
Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy within the framework of the Munich Cluster for Systems Neurology
New Cornerstone Investigator Program
Ministry of Science and Technology of China
Max-Planck Society
Max-Planck-Gesellschaft (Max Planck Society)
New Cornerstone Investigator Program
Ministry of Science and Technology of China
Max-Planck Society
Max-Planck-Gesellschaft (Max Planck Society)