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Chun, S.H.* ; Yoon, D.E.* ; Diaz Almeida, D.S.* ; Todorov, M.I. ; Straub, T.* ; Ruff, T.* ; Shao, W.* ; Yang, J.* ; Seyit-Bremer, G.* ; Shen, Y.R.* ; Ertürk, A. ; Del Toro, D.* ; Shi, S.* ; Klein, R.*

Cortex folding by combined progenitor expansion and adhesion-controlled neuronal migration.

Nat. Commun. 16:8048 (2025)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
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Folding of the mammalian cerebral cortex into sulcal fissures and gyral peaks is the result of complex processes that are incompletely understood. Previously we showed that genetic deletion of Flrt1/3 adhesion molecules causes folding of the smooth mouse cortex into sulci resulting from increased lateral dispersion and faster neuron migration, without progenitor expansion. Here, we show in mice that combining the Flrt1/3 double knockout with an additional genetic deletion that causes progenitor expansion, greatly enhances cortex folding. Expansion of intermediate progenitors by deletion of Cep83 leads to a relative increase in Flrt-mutant neurons resulting in enhanced formation of sulci. Expansion of apical progenitors by deletion of Fgf10 leads to a relative reduction in Flrt-mutant neurons resulting in enhanced formation of gyri. These results together with computational modeling identify key developmental mechanisms, such as adhesive properties, cell densities and migration of cortical neurons, that cooperate to promote cortical gyrification.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Cerebral-cortex; Radial Glia; Cell-proliferation; Brain; Size; Differentiation; Ferret
Language english
Publication Year 2025
HGF-reported in Year 2025
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Journal Nature Communications
Quellenangaben Volume: 16, Issue: 1, Pages: , Article Number: 8048 Supplement: ,
Publisher Nature Publishing Group
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute for Tissue Engineering and Regenerative Medicine (ITERM)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-505800-001
Grants Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) under Germany's Excellence Strategy within the framework of the Munich Cluster for Systems Neurology
New Cornerstone Investigator Program
Ministry of Science and Technology of China
Max-Planck Society
Max-Planck-Gesellschaft (Max Planck Society)
DOI 10.1038/s41467-025-62858-9
WOS ID 001560932300036
Scopus ID 105014725059
PubMed ID 40877293
Erfassungsdatum 2025-10-17
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