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Arterial stiffness and vascular aging: Mechanisms, prevention, and therapy.
Signal Transduct. Target. Ther. 10:282 (2025)
Cardiovascular diseases are the leading cause of morbidity and mortality worldwide. The central underlying mechanisms of cardiovascular diseases are vascular aging and associated arterial stiffness. Arterial stiffness is characterized by structural (e.g., tunica media calcification, alterations in vascular smooth muscle cells, and fibrosis) and functional (e.g., loss of Windkessel function, elevated pulse pressure, and development of isolated systolic hypertension) vascular changes that cause microvascular dysfunction and end-organ damage (e.g., heart failure, vascular dementia, hypertensive retinopathy, and chronic kidney disease). Current research indicates that arterial stiffness is an independent risk factor for cardiovascular diseases and represents a potential target for personalized prevention and therapeutic approaches. In this review, we summarize the pathophysiological mechanisms of vascular aging and arterial stiffness, outline the resulting end-organ damage, present different methods for the measurement of arterial stiffness, highlight the potential role of prevention and therapy, and provide future perspectives for arterial stiffness research. The purpose of this review is to provide a state-of-the-art interdisciplinary and translational approach to arterial stiffness, highlighting unique pathophysiological mechanisms (e.g., perivascular adipose tissue, extracellular vesicles), clinical relevance, and future directions.
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Publication type
Article: Journal article
Document type
Review
Keywords
Smooth-muscle-cells; Pulse-wave Velocity; Perivascular Adipose-tissue; Chronic Kidney-disease; Small-vessel Disease; Angiotensin-aldosterone System; Inflammatory-bowel-disease; Obstructive Sleep-apnea; Age Estimation Models; Matrix Gla-protein
ISSN (print) / ISBN
2095-9907
e-ISSN
2059-3635
Quellenangaben
Volume: 10,
Issue: 1,
Article Number: 282
Publisher
Nature Publishing Group
Publishing Place
Campus, 4 Crinan St, London, N1 9xw, England
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology (EPI)
Grants
Cardiovascular prevention and sports medicine project (European Regional Development Fund EFRE)
DIKAP project (European Regional Development Fund EFRE)
DZPG (German Center for Mental Health)
Polycarp-Leporin-Program (Medical faculty University Magdeburg)
DIKAP project (European Regional Development Fund EFRE)
DZPG (German Center for Mental Health)
Polycarp-Leporin-Program (Medical faculty University Magdeburg)