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Dekkers, S.* ; Adam, V.* ; Battista, V.D.* ; Haase, A.* ; Prinz, J.* ; Nagel, G.* ; Fransman, W.* ; Persson, M.* ; Suarez-Merino, B.* ; Wohlleben, W.* ; Schmid, O. ; Someren, E.v.*

Safe‐and‐sustainable‐by‐design approach and decision support system for advanced materials.

Adv. Sustain. Syst., DOI: 10.1002/adsu.202500208 (2025)
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To facilitate Safe-and-Sustainable-by-Design (SSbD), the HARMLESS project developed a practical SSbD approach and SSbD Decision Support System (DSS) for advanced materials. The HARMLESS SSbD approach and SSbD-DSS are in alignment with the EU-recommended SSbD framework and methods. The HARMLESS SSbD approach recommends New Approach Methodologies (NAMs) tailored to advanced materials and the innovation stage of the material under development. The approach follows a flexible stage-gate model with three innovation stages: 1) Ideation & Business Case Phase, 2) Lab Phase, and 3) Pilot Phase. The HARMLESS SSbD-DSS guides designers through a workflow starting with the Advanced Material Earliest Assessment (AMEA) tool. AMEA contains three questions enabling categorization and subsequently advice on design principles. A second tool, named Warning flags, Design Advice, Screening Priorities (WASP), consists of 12 questions to identify early warning flags and provide design and assessment advice. A third tool, named Alternative SSbD Design Inspector (ASDI), provides guidance on descriptors to measure in the Lab Phase for informed decision making on the most optimal SSbD version. By adapting the data and resource requirements to each innovation stage, the SSbD-DSS facilitates practical implementation of SSbD, supporting the user to find a transparent balance between safety, sustainability, and performance.
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Publication type Article: Journal article
Document type Review
Keywords advanced materials; decision support system; safe-and-sustainable-by-design; Nanomaterials
Language english
Publication Year 2025
HGF-reported in Year 2025
ISSN (print) / ISBN 2366-7486
e-ISSN 2366-7486
Journal Advanced Sustainable Systems
Publisher Wiley
Publishing Place Postfach 101161, 69451 Weinheim, Germany
Reviewing status Peer reviewed
Institute(s) Institute of Lung Health and Immunity (LHI)
POF-Topic(s) 30202 - Environmental Health
Research field(s) Lung Research
PSP Element(s) G-505000-008
Grants The European Union's Horizon 2020 research and innovation programme
DOI 10.1002/adsu.202500208
WOS ID 001563007600001
Scopus ID 105015319209
Erfassungsdatum 2025-10-17
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