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Integrated single-cell atlas of human atherosclerotic plaques.
Nat. Commun. 16:8255 (2025)
Atherosclerosis, a major cause of cardiovascular diseases, is characterized by the buildup of lipids and chronic inflammation in the arteries, leading to plaque formation and potential rupture. Despite recent advances in single-cell transcriptomics (scRNA-seq), the underlying immune mechanisms and transformations in structural cells driving plaque progression remain incompletely defined. Existing datasets often lack comprehensive coverage and consistent annotations, limiting the utility of downstream analyses. Here, we present an integrated single-cell atlas of human atherosclerotic plaques, covering roughly 250k high-quality annotated cells. We achieve robust cell type annotations validated by expert consensus and surface protein measurements. Using this atlas, we introduce distinct markers for plaque neutrophils, identify a proangiogenic endothelial cell cluster enriched in advanced lesions, and specialized macrophage subsets. We also establish that fibromyocytes are exclusive to vascular tissue. This comprehensive atlas enables accurate automatic cell type annotation of new datasets, improves experimental design by guiding sample size and detection power, and supports the deconvolution of bulk RNA-seq data. An interactive WebUI makes these resources widely accessible.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Vascular-lesions; Histological Classification; Arteriosclerosis; Macrophages; Definition; Committee; Council; Expression; Landscape; Arteries
ISSN (print) / ISBN
2041-1723
e-ISSN
2041-1723
Journal
Nature Communications
Quellenangaben
Volume: 16,
Issue: 1,
Article Number: 8255
Publisher
Nature Publishing Group
Publishing Place
London
Reviewing status
Peer reviewed
Institute(s)
Institute of Computational Biology (ICB)
Grants
Projekt DEAL
DZHK (German Center for Cardiovascular Research)
Chan Zuckerberg Foundation
DFG
Bavarian State Ministry of Health and Care through the DigiMed Bayern project on P4 medicine
ERC Consolidator Grant LongTX
Helmholtz Association
DZHK (German Center for Cardiovascular Research)
Chan Zuckerberg Foundation
DFG
Bavarian State Ministry of Health and Care through the DigiMed Bayern project on P4 medicine
ERC Consolidator Grant LongTX
Helmholtz Association