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Altun, I. ; Vo, K.H.D. ; Walia, S.R. ; Yan, X. ; Singh, I. ; Karlina, R. ; Miok, V. ; Kang, L. ; Reichenbach, V.K. ; Israel, A. ; Lutter, D. ; Perocchi, F. ; Ussar, S.

Igf2 regulates early postnatal DPP4+ preadipocyte pool expansion.

Genes Dev., DOI: 10.1101/gad.352710.125 (2025)
Publ. Version/Full Text Research data DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Adipose tissue is rapidly expanding early in life. Elucidating the queues facilitating this process will advance our understanding of metabolically healthy obesity. Using single-cell RNA sequencing, we identified compositional differences of prewean and adult murine subcutaneous adipose tissue. We identified a dipeptidyl peptidase-4 (Dpp4)-positive precursor population residing in the reticular interstitium of subcutaneous adipose expressing insulin growth factor 2 (Igf2) in prewean mice. We show that IGF2 drives proliferation rather than differentiation in these cells. Moreover, loss of Igf2 in Dpp4 + progenitor cells promotes adipogenesis. Our findings unravel the temporally restricted expression of Igf2 to promote preadipocyte expansion.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Adipose Tissue Development ; Dpp4+ ; Igf2 ; Hyperplasia ; Preadipocyte ; Progenitor Cells
Language english
Publication Year 2025
HGF-reported in Year 2025
ISSN (print) / ISBN 0890-9369
e-ISSN 1549-5477
Journal Genes and Development
Publisher Cold Spring Harbor Laboratory Press
Reviewing status Peer reviewed
Institute(s) Adipocytes & Metabolism (ADM)
Institute of Diabetes and Obesity (IDO)
POF-Topic(s) 30205 - Bioengineering and Digital Health
30201 - Metabolic Health
90000 - German Center for Diabetes Research
Research field(s) Helmholtz Diabetes Center
PSP Element(s) G-507200-001
G-502295-001
G-502200-001
G-501900-004
DOI 10.1101/gad.352710.125
PubMed ID 40930990
Erfassungsdatum 2025-11-04
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