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A consensus guide to preclinical indirect calorimetry experiments.

Nat. Metab. 7, 1765-1780 (2025)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Understanding the complex factors influencing mammalian metabolism and body weight homeostasis is a long-standing challenge requiring knowledge of energy intake, absorption and expenditure. Using measurements of respiratory gas exchange, indirect calorimetry can provide non-invasive estimates of whole-body energy expenditure. However, inconsistent measurement units and flawed data normalization methods have slowed progress in this field. This guide aims to establish consensus standards to unify indirect calorimetry experiments and their analysis for more consistent, meaningful and reproducible results. By establishing community-driven standards, we hope to facilitate data comparison across research datasets. This advance will allow the creation of an in-depth, machine-readable data repository built on shared standards. This overdue initiative stands to markedly improve the accuracy and depth of efforts to interrogate mammalian metabolism. Data sharing according to established best practices will also accelerate the translation of basic findings into clinical applications for metabolic diseases afflicting global populations.
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Publication type Article: Journal article
Document type Review
Keywords Resting Energy-expenditure; Cold-induced Thermogenesis; Diet-induced Obesity; Delta T-cells; Metabolic-rate; Skeletal-muscle; Adipose-tissue; Mouse Model; Body-temperature; Heart-rate
ISSN (print) / ISBN 2522-5812
e-ISSN 2522-5812
Journal Nature metabolism
Quellenangaben Volume: 7, Issue: 9, Pages: 1765-1780 Article Number: , Supplement: ,
Publisher Springer
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Experimental Genetics (IEG)
Institute of Diabetes and Obesity (IDO)
Grants FAPESP
NIH