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Stefani, A.* ; Tang, Q.* ; Clemens, S.* ; DelRosso, L.M.* ; García-Borreguero, D.* ; Ferri, R.* ; Frauscher, B.* ; Holzknecht, E.* ; Provini, F.* ; Schormair, B. ; Winkelman, J.W.* ; Högl, B.*

Sleep related movement disorders: What's new and changing clinical practice.

J. Sleep Res., DOI: 10.1111/jsr.70210:e70210 (2025)
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Restless legs syndrome (RLS) is a common sensorimotor disorder, and the most common sleep-related movement disorder with a prevalence of up to 15% in the European and US population. This review addresses key aspects of RLS, focusing on novel data that have or will likely have an impact on clinical practice. These include novel insights into pathophysiology and motor activity during sleep, with a key focus on implications for RLS treatment. Along this line, we discuss the problem of augmentation before introducing new treatment paradigms and insights into new drug targets from genetics. Besides RLS, restless sleep disorder, neck myoclonus, fragmentary myoclonus, propriospinal myoclonus at the wake-sleep transition, and facio-mandibular myoclonus are discussed. This review provides an overview of the most recent insights into sleep-related movement disorders, and of how they are changing clinical practice.
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Publication type Article: Journal article
Document type Review
Keywords Rls ; Rsdlmm ; Large Muscle Group Movements ; Restless Legs Syndrome ; Restless Sleep Disorder
Language english
Publication Year 2025
HGF-reported in Year 2025
ISSN (print) / ISBN 0962-1105
e-ISSN 0962-1105
Journal Journal of Sleep Research
Quellenangaben Volume: , Issue: , Pages: , Article Number: e70210 Supplement: ,
Publisher Wiley
Publishing Place Oxford
Reviewing status Peer reviewed
Institute(s) Institute of Neurogenomics (ING)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-503200-001
DOI 10.1111/jsr.70210
Scopus ID 105017750380
PubMed ID 41041830
Erfassungsdatum 2025-10-24
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