PuSH - Publication Server of Helmholtz Zentrum München: Closing the gap in behavioral weight loss therapy: Prospective analysis of clinical real-world data of a four-year health insurance-financed program.

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Frenzel, S.V. ; Puls, H.C.* ; Vogl, S.* ; Frölich, F.* ; Felten, H.* ; Schlenz, N.* ; Stumvoll, M. ; Fasshauer, M.* ; Blüher, M. ; Hilbert, A.* ; Schlögl, H.

Closing the gap in behavioral weight loss therapy: Prospective analysis of clinical real-world data of a four-year health insurance-financed program.

Obesities 5:58 (2025)

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	Open Access Gold

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Our four-year interdisciplinary behavioral weight loss program is fully covered by public health insurance for patients with a body mass index of ≥35 kg/m². We evaluated the real-world outcomes of anthropometric, metabolic and psychologic parameters collected prior to the start (t0, n = 381, 71% women) and after each segment of the program (t1–4, n = 243, 126, 94, and 77). It is a prospective evaluation of clinical real-world data including all patients who started the first segment of behavioral treatment until they quit/finished the program. The mean dropout rates per treatment segment were 23%. Body weight after one year decreased from 127.3 kg to 122.2 (p < 0.001). Average hemoglobin A1c value decreased from 5.8% to 5.6% in all patients (p < 0.001) and from 6.6% to 6.2% in patients with type 2 diabetes (p < 0.001). Further metabolic and psychological parameters improved significantly as well. The average weight nadir was reached after two segments, co-occurring with the most beneficial changes in laboratory parameters. Afterwards, mean weight slightly increased accompanied by a discrete loss of benefits in laboratory parameters. Our real-world data with significant health improvements adds important value to discussions about the funding of obesity therapy and thus has the chance to improve therapy availability for obesity patients worldwide.

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0.414