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Gehmeyr, M. ; Rojas López, M.B. ; Nitkunanantharajah, S. ; Preissl, H. ; Vosseler, A. ; Jumpertz von Schwartzenberg, R. ; Birkenfeld, A.L. ; Katsouli, N. ; Fasoula, N.-A. ; Karlas, A. ; Kallmayer, M.* ; Ziegler, A.-G. ; Jüstel, D. ; Ntziachristos, V.

Enhanced maximum intensity projection (eMIP) for improving the fidelity of optoacoustic images.

npj Imaging 3:49 (2025)
Publ. Version/Full Text Research data DOI PMC
Creative Commons Lizenzvertrag
Three-dimensional (3D) image reconstructions are often rendered as two-dimensional images, using maximum intensity projections (MIPs). However, MIP's rendering fidelity depends on the alignment of the individual slices along the projection direction. Also, the presence of noise and artifacts affects the contrast and the projected image elements. We introduce enhanced MIP (eMIP), a methodology that aligns the boundaries (e.g., skin boundary) of adjacent slices of the 3D volume onto the same coordinate system assumed by MIP (e.g., same depth) and applies robust contrast adjustment to normalize the intensities of the projected slices. We benchmark eMIP on 1725 clinical scans of human skin, using raster-scan optoacoustic mesoscopy (RSOM) that were assessed by 8 experts. Our results show that eMIP facilitates interpretability compared to conventional MIP and increases consistently the perceived image quality. The improved diagnostic ability of eMIP has the potential to replace MIP in RSOM and similar modalities.
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Publication type Article: Journal article
Document type Scientific Article
ISSN (print) / ISBN 2948-197X
e-ISSN 2948-197X
Journal npj Imaging
Quellenangaben Volume: 3, Issue: 1, Pages: , Article Number: 49 Supplement: ,
Publisher Springer
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
Institute of Diabetes Research and Metabolic Diseases (IDM)
Institute of Diabetes Research (IDF)