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Scholz, D.* ; Erdur, A.C.* ; Holland, R.* ; Ehm, V.* ; Peeken, J.C. ; Wiestler, B.* ; Rueckert, D.*

Contrastive Anatomy-Contrast Disentanglement: A Domain-General MRI Harmonization Method.

In: (28th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2025, 23-27 September 2025, Daejeon). Berlin [u.a.]: Springer, 2026. 100-110 (Lect. Notes Comput. Sc. ; 15965 LNCS)
DOI
Magnetic resonance imaging (MRI) is an invaluable tool for clinical and research applications. Yet, variations in scanners and acquisition parameters cause inconsistencies in image contrast, hindering data comparability and reproducibility across datasets and clinical studies. Existing scanner harmonization methods, designed to address this challenge face limitations, such as requiring traveling subjects or struggling to generalize to unseen domains. We propose a novel approach using a conditioned diffusion autoencoder with a contrastive loss and domain-agnostic contrast augmentation to harmonize MR images across scanners while preserving subject-specific anatomy. Our method enables brain MRI synthesis from a single reference image. It outperforms baseline techniques, achieving a +7% PSNR improvement on a traveling subjects dataset and +18% improvement on age regression in unseen scanners. Our model provides robust, effective harmonization of brain MRIs to target scanners without requiring fine-tuning. This advancement promises to enhance comparability, reproducibility, and generalizability in multi-site and longitudinal clinical studies, ultimately contributing to improved healthcare outcomes. (The code is publicly available at: https://github.com/daniel-scholz/cacd).
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Publication type Article: Conference contribution
Keywords Contrastive Learning ; Disentanglement ; Domain Generalization ; Scanner Harmonization
Language english
Publication Year 2026
Prepublished in Year 2025
HGF-reported in Year 2025
ISSN (print) / ISBN 0302-9743
e-ISSN 1611-3349
Conference Title 28th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2025
Conference Date 23-27 September 2025
Conference Location Daejeon
Journal Lecture Notes in Computer Science
Quellenangaben Volume: 15965 LNCS, Issue: , Pages: 100-110 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Berlin [u.a.]
Institute(s) Institute of Radiation Medicine (IRM)
POF-Topic(s) 30203 - Molecular Targets and Therapies
Research field(s) Radiation Sciences
PSP Element(s) G-501300-001
DOI 10.1007/978-3-032-04978-0_10
Scopus ID 105017856389
Erfassungsdatum 2025-10-23
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