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Chobola, T. ; Schnabel, J.A. ; Peng, T.

Lightweight Data-Free Denoising for Detail-Preserving Biomedical Image Restoration.

In: (28th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2025, 23-27 September 2025, Daejeon). Berlin [u.a.]: Springer, 2026. 318-327 (Lect. Notes Comput. Sc. ; 15972 LNCS)
DOI
Current self-supervised denoising techniques achieve impressive results, yet their real-world application is frequently constrained by substantial computational and memory demands, necessitating a compromise between inference speed and reconstruction quality. In this paper, we present an ultra-lightweight model that addresses this challenge, achieving both fast denoising and high quality image restoration. Built upon the Noise2Noise training framework–which removes the reliance on clean reference images or explicit noise modeling–we introduce an innovative multistage denoising pipeline named Noise2Detail (N2D). During inference, this approach disrupts the spatial correlations of noise patterns to produce intermediate smooth structures, which are subsequently refined to recapture fine details directly from the noisy input. Extensive testing reveals that Noise2Detail surpasses existing dataset-free techniques in performance, while requiring only a fraction of the computational resources. This combination of efficiency, low computational cost, and data-free approach make it a valuable tool for biomedical imaging, overcoming the challenges of scarce clean training data–due to rare and complex imaging modalities–while enabling fast inference for practical use.
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Publication type Article: Conference contribution
Keywords Image Denoising ; Lightweight ; Self-supervised
Language english
Publication Year 2026
HGF-reported in Year 2026
ISSN (print) / ISBN 0302-9743
e-ISSN 1611-3349
Conference Title 28th International Conference on Medical Image Computing and Computer Assisted Intervention, MICCAI 2025
Conference Date 23-27 September 2025
Conference Location Daejeon
Journal Lecture Notes in Computer Science
Quellenangaben Volume: 15972 LNCS, Issue: , Pages: 318-327 Article Number: , Supplement: ,
Publisher Springer
Publishing Place Berlin [u.a.]
Institute(s) Helmholtz Artifical Intelligence Cooperation Unit (HAICU)
Institute of AI for Health (AIH)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Enabling and Novel Technologies
PSP Element(s) G-530006-001
G-540007-001
DOI 10.1007/978-3-032-05169-1_31
Scopus ID 105018082209
Erfassungsdatum 2025-10-23
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