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Daria, T.* ; Iyer, K.* ; Alkhairo, H.* ; Kho, P.F.* ; Suzuki, K.* ; Hatzikotoulas, K. ; Southam, L. ; Taylor, H.J.* ; Yin, X.* ; Mandla, R.* ; Huerta-Chagoya, A.* ; Rayner, N.W. ; Levin, M.G.* ; Damrauer, S.M.* ; Tsao, P.S.* ; Priest, J.R.* ; Klarin, D.* ; Pirruccello, J.P.* ; Echouffo Tcheugui, J.B.* ; Tcheandjieu, C.*

Mendelian randomization suggests a causal link between glycemic traits and thoracic aortic structures and diseases.

JACC-Basic Transl. Sci. 10:101390 (2025)
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We investigate the relationship between glycemic traits-specifically type 2 diabetes mellitus, fasting glucose, fasting insulin, glycated hemoglobin, and 2-hour post-load glucose-and thoracic aortic morphology and diseases. The results indicate an inverse association between elevated glycemic traits and aortic morphology, as well as a reduced risk of thoracic aortic aneurysm. Genetic predictors related to beta-cell proinsulin mechanisms in type 2 diabetes mellitus drive these associations. Key genes such as AGER, GLRX, TCF7L2, and GCK are implicated, highlighting their potential as therapeutic targets for the prevention and treatment of thoracic aortic aneurysm, given their role in glycemic control medication.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Aortic Aneurysm ; Aortic Tissue Expression ; Glycemic Traits ; Mendelian Randomization ; Type 2 Diabetes
Language english
Publication Year 2025
HGF-reported in Year 2025
ISSN (print) / ISBN 2452-302X
e-ISSN 2452-302X
Journal JACC: Basic to Translational Science
Quellenangaben Volume: 10, Issue: 11, Pages: , Article Number: 101390 Supplement: ,
Publisher Elsevier
Reviewing status Peer reviewed
Institute(s) Institute of Translational Genomics (ITG)
POF-Topic(s) 30205 - Bioengineering and Digital Health
Research field(s) Genetics and Epidemiology
PSP Element(s) G-506700-001
DOI 10.1016/j.jacbts.2025.101390
Scopus ID 105021629571
PubMed ID 41175115
Erfassungsdatum 2025-11-03
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