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Daria, T.* ; Iyer, K.* ; Alkhairo, H.* ; Kho, P.F.* ; Suzuki, K.* ; Hatzikotoulas, K. ; Southam, L. ; Taylor, H.J.* ; Yin, X.* ; Mandla, R.* ; Huerta-Chagoya, A.* ; Rayner, N.W. ; Levin, M.G.* ; Damrauer, S.M.* ; Tsao, P.S.* ; Priest, J.R.* ; Klarin, D.* ; Pirruccello, J.P.* ; Echouffo Tcheugui, J.B.* ; Tcheandjieu, C.*

Mendelian randomization suggests a causal link between glycemic traits and thoracic aortic structures and diseases.

JACC-Basic Transl. Sci. 10:101390 (2025)

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We investigate the relationship between glycemic traits-specifically type 2 diabetes mellitus, fasting glucose, fasting insulin, glycated hemoglobin, and 2-hour post-load glucose-and thoracic aortic morphology and diseases. The results indicate an inverse association between elevated glycemic traits and aortic morphology, as well as a reduced risk of thoracic aortic aneurysm. Genetic predictors related to beta-cell proinsulin mechanisms in type 2 diabetes mellitus drive these associations. Key genes such as AGER, GLRX, TCF7L2, and GCK are implicated, highlighting their potential as therapeutic targets for the prevention and treatment of thoracic aortic aneurysm, given their role in glycemic control medication.

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Publication type Article: Journal article

Document type Scientific Article

Keywords Aortic Aneurysm ; Aortic Tissue Expression ; Glycemic Traits ; Mendelian Randomization ; Type 2 Diabetes; Growth-factor; Variants; Association; Beta; Metaanalysis; Glucokinase; Expansion; Aneurysms; Genetics; Tcf7l2

ISSN (print) / ISBN 2452-302X

e-ISSN 2452-302X

Journal JACC: Basic to Translational Science

Quellenangaben Volume: 10, Issue: 11, Article Number: 101390

Publisher Elsevier

Publishing Place Ste 800, 230 Park Ave, New York, Ny 10169 Usa

Reviewing status Peer reviewed

Institute(s) Institute of Translational Genomics (ITG)

Grants US Department of Veterans Affairs Biomedical Research and Development Award
Doris Duke Foundation