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Creatine kinase B regulates glycolysis and de novo lipogenesis pathways to control lipid accumulation during adipogenesis.
Cell Rep. 44:116489 (2025)
White adipocyte differentiation or adipogenesis requires coordination of metabolic sensing and transcriptional modifications to orchestrate lipid storage. Creatine and its kinases are implicated in adipose energy buffering, but the roles of cytosolic (CKB) and mitochondrial (CKMT2) creatine kinases in adipogenesis are unclear. We find that both CKB and CKMT2 are progressively upregulated during differentiation. Functional studies show that CKB restrains de novo lipogenesis (DNL) by limiting activation of carbohydrate-responsive element-binding protein (ChREBP), a key regulator of lipogenic genes. Mechanistically, CKB interacts with AKT and regulates its activation in response to insulin. Loss of CKB causes persistent AKT-mTORC1 signaling, increases glycolytic flux, and enhances ChREBP activation, thereby promoting glucose-derived lipid synthesis. Thus, CKB acts as a metabolic rheostat linking creatine-kinase activity to insulin signaling and nutrient-responsive transcription. We propose a CKB-AKT-ChREBP regulatory axis that contributes to metabolic remodeling and lipid homeostasis during adipocyte differentiation.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Akt-mtorc ; Ckb ; Cp: Metabolism ; Chrebp ; Adipogenesis ; Creatine Kinase ; De Novo Lipogenesis ; White Adipocyte; Creatine Supplementation Prevents; Depot-specific Differences; Diet-induced Obesity; De-novo Lipogenesis; Adipose-tissue; Human Adipocyte; Insulin-resistance; Mammalian Protein; Gene-expression; Fatty Liver
ISSN (print) / ISBN
2211-1247
e-ISSN
2211-1247
Journal
Cell Reports
Quellenangaben
Volume: 44,
Issue: 11,
Article Number: 116489
Publisher
Cell Press
Publishing Place
50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Reviewing status
Peer reviewed
Institute(s)
Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
Grants
European Research Council (ERC Synergy grant SPHERES)
French National Agency for Research
Swedish Research Council
CIMED, European Foundation for the Study of Diabetes Rising Star award
French National Agency for Research
Swedish Research Council
CIMED, European Foundation for the Study of Diabetes Rising Star award