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Open Access Green as soon as Postprint is submitted to ZB.
Reawakening cAMP signalling in cancer cachexia.
Nat. Metab., DOI: 10.1038/s42255-025-01417-4 (2025)
The question of why muscle wasting persists in cancer cachexia despite adequate nutrition has long since intrigued researchers. Here, the authors identify PDE4D-mediated suppression of cAMP–PKA–CREB1 signalling as a driver of mitochondrial dysfunction and show that PDE4D inhibition preserves muscle bioenergetics and mass in cancer cachexia.
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Publication type
Article: Journal article
Document type
Comment, Opinion
ISSN (print) / ISBN
2522-5812
e-ISSN
2522-5812
Journal
Nature metabolism
Publisher
Springer
Publishing Place
London
Reviewing status
Peer reviewed
Institute(s)
Institute of Diabetes and Cancer (IDC)
Grants
European Research Council (ERC)
German Research Foundation
European Research Council (ERC) under the European Union
German Research Foundation
European Research Council (ERC) under the European Union