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Impact of Wuchereria bancrofti Infection on cervical mucosal immunity and human papillomavirus prevalence in women from Lindi and Mbeya regions, Tanzania.
Trop. Med. Infect. Dis. 10, 20:317 (2025)
We previously described an increased incidence of HIV among individuals infected with Wuchereria bancrofti
(WB). However, no host, parasite, or viral factors were reported as
directly associated with the increase in HIV incidence in this group. To
investigate this, we compared T cell phenotypes between WB+ and WB−
women. Flow cytometry analysis of activation and differentiation markers
on CD4 T cells, as well as HIV entry receptor CCR5 was performed on
cervical and peripheral blood samples from 54 women living without HIV
(WLWoH). Additionally, HPV testing was performed on their specimens and
for 13 WLWH. WB infection was associated with a significantly increased
frequency of CD3+γδ2+ T cells in the cervical mucosa (median 4.0% vs. 1.4%, p
= 0.012). Contrary to our expectations, we found lower frequencies of
CCR5 on total, memory and activated memory CD4 T cells in the WB+ group.
However, differences diminished after accounting for age and site of
recruitment. WB and HIV infections were associated with an increased
likelihood of high-risk human papillomavirus (HR HPV) positivity. (WB
status: odds ratio (OR) 4.1, p = 0.066; HIV status: OR 5.5, p
= 0.068). Our findings suggest immunological mechanisms by which WB
increases the risk for other infections, e.g., HIV and HR HPV, albeit
independent of the CCR5 receptor.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Wuchereria Bancrofti ; Coinfection ; Incidence (geometry) ; Flow Cytometry ; Tanzania ; Immunity ; Odds Ratio ; Hpv Infection; Cd4(+) T-cells; Human Lymphatic Filariasis; Mycobacterium-tuberculosis; Helminth Infections; Southwest Tanzania; Interferon-gamma; Hiv-1 Infection; High-risk; Susceptibility; Activation
ISSN (print) / ISBN
2414-6366
e-ISSN
2414-6366
Quellenangaben
Volume: 10,
Issue: 11,
Pages: 20,
Article Number: 317
Publisher
MDPI
Publishing Place
Mdpi Ag, Grosspeteranlage 5, Ch-4052 Basel, Switzerland
Reviewing status
Peer reviewed
Institute(s)
Research Unit Global Health (UGH)