PuSH - Publication Server of Helmholtz Zentrum München

Kaeuferle, T.* ; Eiz-Vesper, B.* ; Moosmann, A.* ; Behrends, U.* ; Decker, M.* ; Gutjahr, L.* ; Mautner, J. ; Klein, F.* ; Kreer, C.* ; Reger, M.* ; Busch, D.H.* ; D'Ippolito, E.* ; Kohlmayer, F.* ; Menzel, A.* ; Willier, S.* ; Maecker-Kolhoff, B.* ; Feuchtinger, T.*

Guiding antiviral cell therapy approaches with an online resource of clinically scored epitopes, T-cell receptors, and B-cell receptors.

Transfus. Med. Hemother. 52, 350–359 (2025)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Introduction: The clinical application of cell-based immunotherapies is a rapidly emerging field, and recent advances in gene therapy have opened up a new era of innovative treatment approaches. Introducing a specific T-cell receptor (TCR) against viral epitopes or chimeric antigen receptor (CAR) into T cells and effector cells allows reprogramming of their specificity and utilization for advanced therapeutic applications in infectious diseases and virus-induced malignancies. Many technologies have been developed to genetically engineer T cells, and existing databases in silico predict or describe identified viral epitopes, TCRs, or B-cell receptors (BCRs). However, their therapeutic application is still hampered by limited knowledge on their clinical impact. Methods: An open-access online resource was developed, integrating a data-mining algorithm scoring the epitopes, TCRs, and BCRs (ETB database) according to clinical evidence. Results: We hereby present a new level of clinical evidence-based knowledge transfer for selecting individual protective TCRs or BCRs for therapeutic application. The database is publicly available at https://app.bitcare.de/epitopeFrontend/. Conclusion: Redirecting T-cell specificity by genetic engineering using clinically protective TCR or CAR sequences will not only bring significant progress to the field of adoptive T-cell therapies but also lay the groundwork for broader applications such as off-the-shelf approaches.
Altmetric
Additional Metrics?
[➜Log in]
Edit extra informations Login
Publication type Article: Journal article
Document type Scientific Article
Keywords Adoptive T-cell transfer; Antibodies; Antigens; B-cell receptor; Epitope; Immune response; Infections; MHC; T cells; T-cell receptor; Virus; Cytomegalovirus; Infections
ISSN (print) / ISBN 1660-3796
e-ISSN 1424-5493
Journal Transfusion Medicine and Hemotherapy
Quellenangaben Volume: 52, Issue: 6, Pages: 350–359 Article Number: , Supplement: ,
Publisher Karger
Publishing Place Allschwilerstrasse 10, Ch-4009 Basel, Switzerland
Reviewing status Peer reviewed
Institute(s) Institute of Virology (VIRO)
Grants DZIF Group Host Control of Viral Latency and Reactivation, Department of Medicine III, LMU Klinikum, Munich, Germany
German Center for Infection Research (DZIF)