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Advances in incretin-based drug discovery in 2025.

Nat. Rev. Endocrinol., DOI: 10.1038/s41574-025-01219-4 (2025)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
The efficacy of anti-obesity drugs that use glucagon-like peptide 1 receptor agonism and glucose-dependent insulinotropic polypeptide agonism raises critical questions about how next-generation drugs might offer increased metabolic benefits. In 2025, new research into incretin-based treatments has brought us closer to answering these questions.
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Publication type Article: Journal article
Document type Review
ISSN (print) / ISBN 1759-5029
e-ISSN 1759-5037
Publisher Nature Publishing Group
Publishing Place New York, NY
Reviewing status Peer reviewed