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One small molecule for man, one giant leap for mankind with obesity.

Med. 6:100924 (2025)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
The ATTAIN-1 trial launches a new era in obesity care. Orforglipron, the first oral small-molecule GLP-1 receptor agonist to complete a phase 3 clinical trial, delivers meaningful reductions in body weight and improvements in metabolic health. This advancement moves beyond peptide-based injectables, paving the way for potent obesity therapies that are simpler, more affordable, and accessible to millions worldwide.
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Publication type Article: Journal article
Document type Editorial
ISSN (print) / ISBN 2666-6359
e-ISSN 2666-6340
Journal Med (N Y)
Quellenangaben Volume: 6, Issue: 12, Pages: , Article Number: 100924 Supplement: ,
Publisher Elsevier
Publishing Place 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa
Reviewing status Peer reviewed
Grants German Center for Diabetes Research (DZD e.V.)
German Research Foundation
European Union within European Research Council ERC-CoG