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Skerrett-Byrne, D.A. ; Ashton, L.M.* ; Nixon, B.* ; Morgan, P.J.*

Determinants of male fertility in the Western Pacific Region: Environmental, biological, and lifestyle influences.

Lancet Reg. Health-W. Pac. 65:101716 (2025)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Over the past half-century, global fertility rates have declined, with the Western Pacific Region (WPR) experiencing a particularly notable drop. A recent World Health Organisation-commissioned report identified the WPR as exhibiting the highest infertility prevalence at 23.2%, compared to the global average of 17.5%. While the drivers of this decline are complex, one key contributor is male infertility, yet it remains under addressed in research and policy. In this paper, we synthesise current evidence on male infertility with a focus on the WPR. Specifically, we explore environmental, biological, and demographic correlates of male infertility, examine molecular mechanisms regulating sperm function and assess the impact of lifestyle interventions. Our findings highlight significant gaps in regional evidence, advocating for targeted research and culturally tailored interventions to enhance preconception male health within the WPR. Based on this synthesis, we propose preventive strategies and evidence-based recommendations to improve male preconception health in the region.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Assisted Reproductive Technologies ; Environmental Factors ; Epigenetics ; Fertility ; Interventions ; Male Infertility ; Men's Health ; Mental Health ; Nutrition ; Paternal Preconception Health ; Physical Activity ; Sperm ; Sperm Proteomics ; Substance Use ; Transgenerational Health ; Weight Management; In-vitro Fertilization; Advanced Paternal Age; Semen Quality; Psychosocial Interventions; Infertile Couples; Pregnancy Rates; Climate-change; Air-pollution; Heat-stress; Healthy-men
ISSN (print) / ISBN 2666-6065
e-ISSN 2666-6065
Journal The Lancet Regional Health - Western Pacific
Quellenangaben Volume: 65, Issue: , Pages: , Article Number: 101716 Supplement: ,
Publisher Elsevier
Publishing Place Radarweg 29, 1043 Nx Amsterdam, Netherlands
Reviewing status Peer reviewed
Institute(s) Institute of Experimental Genetics (IEG)
Grants NHMRC Emerging Leadership Fellowship
National Health and Medical Research Council (NHMRC)