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The nature of sex differences in catecholamine-induced lipolysis in subcutaneous fat cells.
iScience 28:113988 (2025)
Women demonstrate a more efficient energy metabolism than men, which is important for sex differences in metabolic health. This dimorphism involves a greater capacity to mobilize lipids from adipose tissue through triglyceride lipolysis following catecholamine stimulation. Herein, we examined the cellular nature of this dimorphism of catecholamine action in human adipocytes from subcutaneous adipose tissue by combining extensive pharmacological experiments with descriptive proteome and transcriptome analyses in large cohorts. We observed two sex-dependent differences in catecholamine-stimulated adipocyte lipolysis: in women, the lipolytic sensitivity (half maximum effective hormone concentration) was 50% decreased, involving increased coupling of antilipolytic alpha-2A adrenoceptors to adenylyl cyclase. However, the maximum lipolytic hormone effect was 50% increased and linked to more efficient mono- and triacylglycerol lipases. Treatment targeting adipocyte lipolysis might be used in men to diminish sex differences in the regulation of lipid metabolism.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Human Metabolism ; Lipid ; Omics; Tissue Gene-expression; Adipose-tissue; Weight-loss; Metabolic Complications; Adrenergic Regulation; Regional Differences; Gluteal Adipocytes; Lipid Mobilization; Insulin-resistance; Obesity
ISSN (print) / ISBN
2589-0042
e-ISSN
2589-0042
Journal
iScience
Quellenangaben
Volume: 28,
Issue: 12,
Article Number: 113988
Publisher
Elsevier
Publishing Place
Amsterdam ; Bosten ; London ; New York ; Oxford ; Paris ; Philadelphia ; San Diego ; St. Louis
Reviewing status
Peer reviewed
Institute(s)
Helmholtz Institute for Metabolism, Obesity and Vascular Research (HI-MAG)
Grants
German Diabetes Association
European Association for the Study of Diabetes
Swedish Research Council
Swedish Society of Medicine
Strategic Program for Diabetes Research and Center for Innovative Medicine at Karolinska Institutet
Stockholm County Council
European Association for the Study of Diabetes
Swedish Research Council
Swedish Society of Medicine
Strategic Program for Diabetes Research and Center for Innovative Medicine at Karolinska Institutet
Stockholm County Council