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Sidoroff, V.* ; Moradi, H.* ; Prigent, G.* ; Jagusch, F.* ; Teckenburg, I.* ; Asalian, M.* ; Hergenroeder-Lenzner, N.* ; Giraitis, M.* ; Schoenfeldt-Reichmann, E.T.* ; Ndayisaba, J.P.* ; Goebel, G.* ; Seppi, K.* ; Ionescu, A.* ; Krismer, F.* ; Benninger, D.* ; Winkler, J.* ; Eskofier, B.M. ; Klucken, J.* ; Aminian, K.* ; Wenning, G.* ; Sapienza, S.* ; Gassner, H.* ; Raccagni, C.*

Moving beyond the hospital: In-depth characterization of daily-life mobility in patients with atypical Parkinsonian disorders.

npj Parkinsons Dis. 12:34 (2026)
Publ. Version/Full Text Research data DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
This study evaluates mobility in patients with multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and Parkinson's disease (PD) by integrating clinical assessments, instrumented gait analysis (IGA) in the hospital, and 1 week of physical activity monitoring (PAM) at home, using wearable sensors. Clinical scores provide a broad measure of disease severity but lack precision in quantifying gait impairments. IGA offers objective gait metrics under standardized conditions, identifying deficits in stride dynamics and postural control. However, these controlled assessments do not reflect real-world mobility. PAM addresses this gap by continuously tracking movement patterns and physical activity during daily-life, offering insights into how patients walk beyond clinical settings. The combination of IGA and PAM provides a more comprehensive understanding of mobility limitations, particularly in MSA and PSP, where gait and balance impairments differ from PD. This dual approach enhances patient assessment, supports personalized disease management, and improves clinical decision-making. Trial registration: ClinicalTrials.gov, NCT04608604, date of registration: 19/10/2020, first patient enrollment: 01/02/2021.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Progressive Supranuclear Palsy; Disease; Questionnaire; Reliability; Intensity; Diagnosis; Falls
ISSN (print) / ISBN 2373-8057
e-ISSN 2373-8057
Journal npj Parkinson's Disease
Quellenangaben Volume: 12, Issue: 1, Pages: , Article Number: 34 Supplement: ,
Publisher Springer
Publishing Place Heidelberger Platz 3, Berlin, 14197, Germany
Reviewing status Peer reviewed
Institute(s) Institute of AI for Health (AIH)
Grants Fonds national de la Recherche Luxembourg
Schweizerischer Nationalfonds zur Forderung der Wissenschaftlichen Forschung
Deutsche Forschungsgemeinschaft
Austrian Science Fund