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Open Access Green as soon as Postprint is submitted to ZB.
Possible association between genetic variants at the GRIN1 gene and schizophrenia with lifetime history of depressive symptoms in a German sample.
Psychiatr. Genet. 17, 308-310 (2007)
Genetic variation in glutamatergic signalling pathways is believed to play a substantial role in the aetiology of schizophrenia. The N-methyl-D-aspartate receptor subunit gene GRIN1 has been proposed as a candidate gene for schizophrenia. We tested for a potential association between schizophrenia and four single nucleotide polymorphisms (rs4880213, rs11146020, rs6293, and rs10747050) and one microsatellite marker at GRIN1 in a German sample of 354 patients and 323 controls. We found significant associations in single-marker and haplotype-based analyses (P<0.05). Significance was more pronounced (P<0.01) in the subset of patients with a lifetime history of major depression, a subgroup of schizophrenia described previously as a promising phenotypic subtype in genetic studies of schizophrenia. Although significances did not withstand correction for multiple testing, the results of our exploratory analysis warrant further studies on GRIN1 and schizophrenia.
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Publication type
Article: Journal article
Document type
Scientific Article
Keywords
affective disorder; depression; glutamate; genotype-phenotype correlation; N-methyl-D-aspartate; psychosis
ISSN (print) / ISBN
0955-8829
e-ISSN
1473-5873
Journal
Psychiatric Genetics
Quellenangaben
Volume: 17,
Issue: 5,
Pages: 308-310
Publisher
Lippincott Williams & Wilkins
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
Institute of Epidemiology (EPI)