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Yang, L.* ; Ru, J. ; Guo, S.* ; Yang, X.* ; Li, P.* ; Deng, L. ; Wang, X.*

Research note: The chicken gut virome: Spatiotemporal dynamics and divergent responses to antibiotic versus phytogenic supplementation.

Poult. Sci. 105:106373 (2026)

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This study employed metagenomic sequencing data to comprehensively investigate the gut virome, with a focus on the bacteriophage communities (the phageome), across intestinal regions and developmental stages in 360 chickens. We characterized the spatiotemporal dynamics of phage communities and assessed the impact of chlortetracycline (CTC), an antibiotic, and Macleaya cordata extract (MCE), a phytogenic supplement. Our analysis revealed that phage community assembly was highly structured, exhibiting distinct successional patterns across age and between foregut and hindgut segments. A key finding was the identification of a potential antibiotic-phage synergy, mediated by phage-encoded auxiliary metabolic genes (AMGs) involved in bacterial immune evasion, suggesting a novel mechanism for enhanced infectivity under antibiotic pressure. In contrast, phytogenic supplementation promoted gut ecosystem homeostasis by fostering significantly richer and more diverse phage communities. Our results delineate the fundamental ecology of the chicken gut virome and provide mechanistic insights into how different growth promoters exert contrasting effects on viral populations, supporting the use of phytogenics as sustainable alternatives for animal husbandry.

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Publication type Article: Journal article

Document type Scientific Article

Keywords Antibiotic Alternative ; Feed Additives ; Gut Virome ; Phage-bacteria Interaction ; Phytogenics

ISSN (print) / ISBN 0032-5791

e-ISSN 1525-3171

Journal Poultry Science

Quellenangaben Volume: 105, Issue: 3, Article Number: 106373

Publisher Elsevier

Publishing Place Radarweg 29, 1043 Nx Amsterdam, Netherlands

Reviewing status Peer reviewed

Institute(s) Institute of Virology (VIRO)

Grants European Research Council Starting grant (ERC)
Deutsche Forschungsgemeinschaft (DFG)
China Agriculture Research System of MOF and MARA
National Key R & D Program of China