Home
Login
Deutsch
Advanced Search
Browse by ...
Publication overview
Contact persons
Help
DOI
PMC
 |
|
as soon as is submitted to ZB.
Associations of physical activity and sedentary behaviors with mortality: An observational analysis and Mendelian randomization study.
Geriatr. Nurs. 68:103834 (2026)
BACKGROUND: To investigate the associations of physical activity (PA) and sedentary behavior (SB) with the risk of mortality using observational and Mendelian randomization (MR) designs. METHODS: In a prospective cohort study based on UK Biobank, data on PA and SB were collected and categorized as three mutually exclusive groups. Multivariable-adjusted Cox models and two-sample MR analysis were performed. RESULTS: Compared with low total PA (TPA), intermediate and high TPA were associated with a decreased risk of all-cause and cardiovascular disease (CVD) mortality. Compared with low levels, high total sitting time and television viewing time were associated with increased risk of all-cause and CVD mortality. The two-sample MR analysis indicated no causal relationship between genetic predispositions to PA/SB and mortality. CONCLUSIONS: Although PA was associated with a lower risk, prolonged sitting time was associated with an increased risk of all-cause and CVD mortality, two-sample MR did not support a causal effect.
Altmetric
Additional Metrics?
Edit extra informations
Login
Publication type
Article: Journal article
Document type
Scientific Article
Keywords
Epidemiology ; Mendelian Randomization ; Mortality ; Physical Activity ; Sedentary Behavior; Adults; Time; Inactivity; Disease; Risk
ISSN (print) / ISBN
0197-4572
e-ISSN
1528-3984
Journal
Geriatric Nursing
Quellenangaben
Volume: 68,
Article Number: 103834
Publisher
Elsevier
Publishing Place
360 Park Avenue South, New York, Ny 10010-1710 Usa
Reviewing status
Peer reviewed
Institute(s)
Institute of Translational Genomics (ITG)