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Solodko, T.* ; Gimino, I.* ; Chandiwala, A.* ; Alkotub, Ab. ; Bashiri Dezfouli, A.* ; Reith, H.* ; Bakhtiar, A.* ; Hicsanmaz, R.* ; Brenner, J.* ; Kaiser, C.J.O.* ; Belli, E.* ; Pandey, S.* ; Rabkin, S.D.* ; Nielsch, K.* ; Multhoff, G.* ; Hayden, O.* ; Hasanzadeh Kafshgari, M.*

Multiphysics-driven assembly of biomimetic vesicles.

Adv. Mater. 38:e18755 (2026)
Publ. Version/Full Text Research data DOI PMC
Open Access Hybrid
Creative Commons Lizenzvertrag
Artificial extracellular vesicles (AEVs) are programmable, biomimetic materials that combine the structural and biological complexity of naturally secreted extracellular vesicles (NEVs) with the design flexibility of synthetic nanomaterials. A multiphysics-driven microfluidics is developed to efficiently integrate the nanoknife-assisted membrane rupture with flow dynamics and acoustothermal modulation for the reproducible, high-yield, scalable, and standardized production of AEVs. Compared to empirical mechanical processes, this integrated microfluidic workflow, which exploits physical and biological insights for EV production, enables multiphysics-based predictions for a precise control of material inputs, flow dynamics, and cell-knife interactions within the channel. The biomimetic AEVs developed through this integrated, optimized single-flow platform, with a sustained and efficient therapeutic encapsulation process, preserve native protein architectures to conduct biomimetic mechanisms of immune modulation and homologous targeting. The standardizable microfluidic platform paves the way for a structure-process-function design strategy, enabling the formation of scalable, adaptive biomaterials for the development of bioinspired interfacial engineering and biomedicine.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Cell Membranes ; Extracellular Vesicles ; Microfluidic Platforms ; Multiphysics; Cell-membrane; Nanoparticles; Nanovesicles; Delivery; Insights
ISSN (print) / ISBN 0935-9648
e-ISSN 1521-4095
Journal Advanced materials
Quellenangaben Volume: 38, Issue: 13, Pages: , Article Number: e18755 Supplement: ,
Publisher Wiley
Publishing Place Weinheim
Reviewing status Peer reviewed
Institute(s) Institute of Biological and Medical Imaging (IBMI)
Grants TranslaTUM Seed Fund (Technical University of Munich)