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Schneider, F.* ; Hoster, E.* ; Unterhalt, M.* ; Schneider, S.* ; Dufour, A.* ; Benthaus, T.* ; Mellert, G.* ; Zellmeier, E.* ; Kakadia, P.M.* ; Bohlander, S.K. ; Feuring-Buske, M.* ; Buske, C.* ; Braess, J.* ; Heinecke, A.* ; Sauerland, M.C.* ; Berdel, W.E.* ; Büchner, T.* ; Wörmann, B.J.* ; Hiddemann, W. ; Spiekermann, K.

The FLT3ITD mRNA level has a high prognostic impact in NPM1 mutated, but not in NPM1 unmutated, AML with a normal karyotype.

Blood 119, 4383-4386 (2012)
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The impact of a FLT3-internal tandem duplication (FLT3ITD) on prognosis of patients with acute myeloid leukemia (AML) is dependent on the ratio of mutated to wild-type allele. In 648 normal karyotype (NK) AML patients, we found a significant independent effect of the quantitative FLT3ITD mRNA level-measured as (FLT3ITD/wtFLT3)/(FLT3ITD/wtFLT3 + 1)-on outcome. Moreover, this effect was clearly seen in 329 patients with a mutated NPM1 gene (NPM1(+)), but not in 319 patients without a NPM1 mutation (wtNPM1). In a multivariate Cox regression model, the quantitative FLT3ITD mRNA level showed an independent prognostic impact on overall survival (OS) and relapse-free survival (RFS) only in the NPM1(+) subgroup (OS: hazard ratio, 5.9; [95% confidence interval [CI]: 3.1-11.2]; RFS: hazard ratio, 7.5 [95% CI: 3.4-16.5]). The FLT3ITD mRNA level contributes to relapse risk stratification and might help to guide postremission therapy in NPM1-mutated AML.
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Publication type Article: Journal article
Document type Scientific Article
Keywords ACUTE MYELOID-LEUKEMIA; ACUTE MYELOGENOUS LEUKEMIA; GENE-MUTATIONS; FAVORABLE PROGNOSIS; NORMAL CYTOGENETICS; POOR-PROGNOSIS; NUCLEOPHOSMIN; ADULTS
Language
Publication Year 2012
HGF-reported in Year 2012
ISSN (print) / ISBN 0006-4971
e-ISSN 1528-0020
Journal Blood
Quellenangaben Volume: 119, Issue: 19, Pages: 4383-4386 Article Number: , Supplement: ,
Publisher American Society of Hematology
Reviewing status Peer reviewed
Institute(s) CCG Pathogenesis of Acute Myeloid Leukemia (KKG-KPL)
POF-Topic(s) 30504 - Mechanisms of Genetic and Environmental Influences on Health and Disease
Research field(s) Immune Response and Infection
PSP Element(s) G-521000-001
PubMed ID 22374696
DOI 10.1182/blood-2010-12-327072
WOS ID WOS:000305286900011
Scopus ID 84860914670
Erfassungsdatum 2012-07-12
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