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History of protein-protein interactions: From egg-white to complex networks.
Proteomics 12, 1478-1498 (2012)
Today, it is widely appreciated that proteinprotein interactions play a fundamental role in biological processes. This was not always the case. The study of protein interactions started slowly and evolved considerably, together with conceptual and technological progress in different areas of research through the late 19th and the 20th centuries. In this review, we present some of the key experiments that have introduced major conceptual advances in biochemistry and molecular biology, and review technological breakthroughs that have paved the way for today's systems-wide approaches to proteinprotein interaction analysis.
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Publication type
Article: Journal article
Document type
Review
Keywords
Cholinergic Receptor Protein; Avian-sarcoma Virus; Control Gene Cdc2+; Saccharomyces-cerevisiae Genome; Maturation-promoting Factor; Small-molecule Inhibitors; Epidermal Growth-factor; Rabbit Skeletal Muscle; Cell-division Cycle; Open Reading Frames; Biochemistry; History; Networks; Protein-protein Interactions; Signaling Pathways; Systems Biology
ISSN (print) / ISBN
1615-9853
e-ISSN
1615-9861
Journal
Proteomics
Quellenangaben
Volume: 12,
Issue: 10,
Pages: 1478-1498
Publisher
Wiley
Non-patent literature
Publications
Reviewing status
Peer reviewed
Institute(s)
CF Metabolomics & Proteomics (CF-MPC)