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Braun, P. ; Gingras, A.C.*

History of protein-protein interactions: From egg-white to complex networks.

Proteomics 12, 1478-1498 (2012)
DOI PMC
Open Access Green as soon as Postprint is submitted to ZB.
Today, it is widely appreciated that proteinprotein interactions play a fundamental role in biological processes. This was not always the case. The study of protein interactions started slowly and evolved considerably, together with conceptual and technological progress in different areas of research through the late 19th and the 20th centuries. In this review, we present some of the key experiments that have introduced major conceptual advances in biochemistry and molecular biology, and review technological breakthroughs that have paved the way for today's systems-wide approaches to proteinprotein interaction analysis.
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Publication type Article: Journal article
Document type Review
Corresponding Author
Keywords Cholinergic Receptor Protein; Avian-sarcoma Virus; Control Gene Cdc2+; Saccharomyces-cerevisiae Genome; Maturation-promoting Factor; Small-molecule Inhibitors; Epidermal Growth-factor; Rabbit Skeletal Muscle; Cell-division Cycle; Open Reading Frames; Biochemistry; History; Networks; Protein-protein Interactions; Signaling Pathways; Systems Biology
ISSN (print) / ISBN 1615-9853
e-ISSN 1615-9861
Journal Proteomics
Quellenangaben Volume: 12, Issue: 10, Pages: 1478-1498 Article Number: , Supplement: ,
Publisher Wiley
Non-patent literature Publications
Reviewing status Peer reviewed