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Kamiza, A.B.* ; Chikowore, T.* ; Chen, G.* ; Ojewunmi, O.* ; Machipisa, T.* ; Zhou, F.* ; Mayanja, R.* ; Toure, S.* ; Soremekun, O. ; Kintu, C.* ; Nakabuye, M.* ; Koprulu, M.* ; Kalungi, A.* ; Kalyesubula, R.* ; Salako, B.* ; Nashiru, O.* ; Corpas, M.* ; Robinson-Cohen, C.* ; Franceschini, N.* ; Pattaro, C.* ; Köttgen, A.* ; Nitsch, D.* ; Langenberg, C.* ; Tcheandjieu, C.* ; Nyirenda, M.* ; Morris, A.P.* ; Asimit, J.* ; Zeggini, E. ; Rotimi, C.* ; Ramsay, M.* ; Adeyemo, A.* ; Fabian, J.* ; Crampin, A.C.* ; Brandenburg, J.T.* ; Fatumo, S.*

KidneyGenAfrica multi-cohort Genome-wide association study and polygenic prediction of kidney function in 110,000 Africans.

Nat. Commun. 17:2599 (2026)
Publ. Version/Full Text DOI PMC
Open Access Gold
Creative Commons Lizenzvertrag
Kidney disease disproportionately affects populations of African ancestry, yet most genetic studies have focused on Europeans. Here, we present a three-stage genome-wide association study meta-analysis of estimated glomerular filtration rate in ~26,000 individuals across Eastern, Western, and Southern Africa and ~81,000 African-ancestry individuals in the diaspora. Continental African meta-analysis identifies four independent genome-wide significant loci, including two previously unreported loci. Pan-African meta-analysis identifies 19 independent loci, including three previously unreported loci. Fine-mapping reveals four loci with high causality probability, and phenome-wide analyses demonstrate pleiotropic effects on cardiometabolic and immunological traits. Notably, APOL1 high-risk variants strongly associated with kidney disease in African Americans show markedly lower frequency and attenuated effects in continental Africa, indicating potential distinct genetic architectures. Polygenic scores from genetically similar populations significantly outperformed those from distant cohorts. These findings demonstrate the necessity of conducting genomic research across diverse African populations to enable equitable health outcomes.
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Publication type Article: Journal article
Document type Scientific Article
Keywords Genome-wide Association Study ; Kidney Disease ; Genetic Association ; Disease ; Renal Function ; Causality (physics) ; Genetic Variation ; Genetic Variants; Disease; Populations; Insights; Metaanalysis; Discovery; Variants; Origins; History; Decline; Biobank
ISSN (print) / ISBN 2041-1723
e-ISSN 2041-1723
Journal Nature Communications
Quellenangaben Volume: 17, Issue: 1, Pages: , Article Number: 2599 Supplement: ,
Publisher Springer
Publishing Place London
Reviewing status Peer reviewed
Institute(s) Institute of Translational Genomics (ITG)
Grants Wellcome Trust (Wellcome)
RCUK | Medical Research Council (MRC)