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Liu, J.* ; Grapin-Botton, A.

Benchmarking in vivo and in vitro gene co-expression networks enables efficient β-like cell differentiation.

Dev. Cell 61, 229-231 (2026)

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Open Access Green as soon as Postprint is submitted to ZB.

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In this issue of Developmental Cell, Yu et al.¹ reconstruct human embryonic gene co-expression networks (GCNs) that guide pancreatic endocrine lineage specification. Benchmarking stem cell-derived islet (SC-islet) differentiation protocols against fetal human pancreatic cells reveals early regulatory divergences, thereby enabling the design of a protocol with improved β-like cell production.

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Publication type Article: Journal article

Document type Editorial

ISSN (print) / ISBN 1534-5807

e-ISSN 1878-1551

Journal Developmental Cell

Quellenangaben Volume: 61, Issue: 2, Pages: 229-231

Publisher Elsevier

Publishing Place 50 Hampshire St, Floor 5, Cambridge, Ma 02139 Usa

Reviewing status Peer reviewed

Institute(s) Institute of Pancreatic Islet Research (IPI)